New polyphenolic β-lactams with antioxidant activity

被引：19

作者：

Cainelli, Gianfranco ^{[1
]}

Angeloni, Cristina ^{[2
]}

Cervellati, Rinaldo ^{[1
]}

Galletti, Paola ^{[1
]}

Giacomini, Daria ^{[1
]}

Hrelia, Silvana ^{[2
]}

Sinisi, Riccardo ^{[1
]}

机构：

[1] Univ Bologna, Dipartimento Chim G Ciamician, I-40126 Bologna, Italy

[2] Univ Bologna, Dipartimento Biochim G Moruzzi, I-40126 Bologna, Italy

来源：

CHEMISTRY & BIODIVERSITY | 2008年 / 5卷 / 05期

关键词：

D O I：

10.1002/cbdv.200890077

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 [生物化学与分子生物学]; 081704 [应用化学];

摘要：

Novel 4-alkylidene-beta-lactams with a polyphenolic side chain were synthesized and evaluated as radical scavengers. We have undertaken a detailed study of the antioxidant activity in vitro with chemical and biological testing of the new beta-lactams and of the corresponding methyl polyhydroxy benzoates. Antioxidant activity of beta-lactams and methyl benzoates was measured with the Briggs-Rauscher oscillating reaction, the TEAC (Trolox (R) Equivalent Antioxidant Capacity) assay, and as ability to inhibit ROS (= Reactive Oxygen Species) production on myoblast H9c2 cells. The results were discussed with regard to mechanism and correlated with structural parameters.

引用

页码：811 / 829

页数：19

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