Tumour-targeted nanomedicines: principles and practice

被引：430

作者：

Lammers, T. ^{[1
]}

Hennink, W. E. ^{[1
]}

Storm, G. ^{[1
]}

机构：

[1] Univ Utrecht, Utrecht Inst Pharmaceut Sci, Dept Pharmaceut, NL-3584 CA Utrecht, Netherlands

来源：

BRITISH JOURNAL OF CANCER | 2008年 / 99卷 / 03期

关键词：

drug targeting; nanomedicines; liposomes; polymers;

D O I：

10.1038/sj.bjc.6604483

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Drug targeting systems are nanometre-sized carrier materials designed for improving the biodistribution of systemically applied ( chemo) therapeutics. Various different tumour-targeted nanomedicines have been evaluated over the years, and clear evidence is currently available for substantial improvement of the therapeutic index of anticancer agents. Here, we briefly summarise the most important targeting systems and strategies, and discuss recent advances and future directions in the development of tumour-targeted nanomedicines.

引用

页码：392 / 397

页数：6

共 32 条

[1] Ligand-targeted therapeutics in anticancer therapy [J].

Allen, TM .

NATURE REVIEWS CANCER, 2002, 2 (10) :750-763

[2] Recent progress in dendrimer-based nanocarriers [J].

Bai, Shuhua ;

Thomas, Chandan ;

Rawat, Amit ;

Ahsan, Fakhrul .

CRITICAL REVIEWS IN THERAPEUTIC DRUG CARRIER SYSTEMS, 2006, 23 (06) :437-495

[3] DIFFUSION OF UNIVALENT IONS ACROSS LAMELLAE OF SWOLLEN PHOSPHOLIPIDS [J].

BANGHAM, AD ;

STANDISH, MM ;

WATKINS, JC .

JOURNAL OF MOLECULAR BIOLOGY, 1965, 13 (01) :238-+

[4] Cationic polymer based gene delivery systems [J].

De Smedt, SC ;

Demeester, J ;

Hennink, WE .

PHARMACEUTICAL RESEARCH, 2000, 17 (02) :113-126

[5] Paclitaxel poliglumex (PPX-xyotax) and concurrent radiation for esophageal and gastric cancer - A phase I study [J].

Dipetrillo, Tom ;

Milas, Luka ;

Evans, Devon ;

Akerman, Paul ;

Ng, Thomas ;

Miner, Tom ;

Cruff, Dennis ;

Chauhan, Bharti ;

Iannitti, David ;

Harrington, David ;

Safran, Howard .

AMERICAN JOURNAL OF CLINICAL ONCOLOGY-CANCER CLINICAL TRIALS, 2006, 29 (04) :376-379

[6]

Drummond DC, 1999, PHARMACOL REV, V51, P691

[7] Polymer conjugates as anticancer nanomedicines [J].

Duncan, Ruth .

NATURE REVIEWS CANCER, 2006, 6 (09) :688-701

[8] Phase III trial of nanoparticle albumin-bound paclitaxel compared with polyethylated castor oil-based paclitaxel in women with breast cancer [J].

Gradishar, WJ ;

Tjulandin, S ;

Davidson, N ;

Shaw, H ;

Desai, N ;

Bhar, P ;

Hawkins, M ;

O'Shaughnessy, J .

JOURNAL OF CLINICAL ONCOLOGY, 2005, 23 (31) :7794-7803

[9] CARRIER POTENTIAL OF LIPOSOMES IN BIOLOGY AND MEDICINE .2. [J].

GREGORIADIS, G .

NEW ENGLAND JOURNAL OF MEDICINE, 1976, 295 (14) :765-770

[10] Intracellular delivery of large molecules and small particles by cell-penetrating proteins and peptides [J].

Gupta, B ;

Levchenko, TS ;

Torchilin, VP .

ADVANCED DRUG DELIVERY REVIEWS, 2005, 57 (04) :637-651

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