Acyl radical cyclisation onto pyrroles

被引：55

作者：

Allin, SM ^{[1
]}

Barton, WRS

Bowman, WR

McInally, T

机构：

[1] Univ Loughborough, Dept Chem, Loughborough LE11 3TU, Leics, England

[2] AstraZeneca R&D Charnwood, Loughborough LE11 5RH, Leics, England

来源：

TETRAHEDRON LETTERS | 2001年 / 42卷 / 44期

基金：

英国工程与自然科学研究理事会;

关键词：

acyl radicals; radical cyclisation; acyl selenides; heteroarenes; tributyltin hydride;

D O I：

10.1016/S0040-4039(01)01639-2

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Synthetically useful [1,2-a]-fused pyrroles, e.g. 2,3-dihydro-1H-pyrrolizidines substituted in the 1- and 7-positions, have been generated by acyl radical cyclisation onto pyrroles using N-(omega -acyl)-radicals generated front acyl-selenide precursors. The protocol does not require high pressures of CO. Mechanistic studies indicate the key role of azo radical initiators as oxidants of the intermediate pi -radicals. (C) 2001 Elsevier Science Ltd. All rights reserved.

引用

页码：7887 / 7890

页数：4

共 22 条

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