Allostatic load biomarkers of chronic stress and impact on health and cognition

被引：1700

作者：

Juster, Robert-Paul ^{[1
]}

McEwen, Bruce S. ^{[2
]}

Lupien, Sonia J. ^{[1
]}

机构：

[1] Univ Montreal, Lab Psychoneuroendocrinol, Ctr Studies Human Stress, Fernand Seguin Res Ctr, Montreal, PQ H3C 3J7, Canada

[2] Rockefeller Univ, Harold & Margaret Milliken Hatch Lab Neuroendocri, New York, NY USA

来源：

NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS | 2010年 / 35卷 / 01期

关键词：

Allostatic load; Chronic stress; Aging; Resilience; Health; Cognition; Biomedicine; CUMULATIVE BIOLOGICAL RISK; CHRONIC-FATIGUE-SYNDROME; 3RD NATIONAL-HEALTH; PHYSIOLOGICAL DYSREGULATION; METABOLIC SYNDROME; SOCIOECONOMIC-STATUS; SOCIAL RELATIONSHIPS; CARDIOVASCULAR RISK; GLUCOSE ALLOSTASIS; PERCEIVED STRESS;

D O I：

10.1016/j.neubiorev.2009.10.002

中图分类号：

B84 [心理学]; C [社会科学总论]; Q98 [人类学];

学科分类号：

03 ; 0303 ; 030303 ; 04 ; 0402 ;

摘要：

The allostatic load model expands the stress-disease literature by proposing a temporal cascade of multi-systemic physiological dysregulations that contribute to disease trajectories. By incorporating an allostatic load index representing neuroendocrine, immune, metabolic, and cardiovascular system functioning, numerous studies have demonstrated greater prediction of morbidity and mortality over and beyond traditional detection methods employed in biomedical practice. This article reviews theoretical and empirical work using the allostatic load model vis-a-vis the effects of chronic stress on physical and mental health. Specific risk and protective factors associated with increased allostatic load are elucidated and policies for promoting successful aging are proposed. (C) 2009 Elsevier Ltd. All rights reserved.

引用

页码：2 / 16

页数：15

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