Expression of frizzled genes in mouse costochondral chondrocytes

被引：9

作者：

Xu, L

Tan, LJ

Goldring, MB

Olsen, BR

Li, YF

机构：

[1] Harvard Univ, Sch Dent Med, Dept Growth & Dev, Boston, MA 02115 USA

[2] Beth Israel Deaconess Med Ctr, Div Rheumatol, Boston, MA 02115 USA

[3] Harvard Univ, Inst Med, New England Baptist Bone & Joint Inst, Boston, MA 02115 USA

[4] Harvard Univ, Forsyth Dept Oral Biol, Boston, MA 02115 USA

[5] Harvard Univ, Sch Med, Dept Cell Biol, Boston, MA 02115 USA

来源：

MATRIX BIOLOGY | 2001年 / 20卷 / 02期

关键词：

D O I：

10.1016/S0945-053X(00)00138-4

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Protein products of frizzled genes are cell membrane receptors for Wnt proteins that play multiple roles during development. We examined the expression of nine frizzled genes in mouse chondrocytes, and detected transcripts of six of the nine genes. We also cloned the entire cDNA of mouse frizzled-l and compared its cDNA sequence and the cysteine-rich and transmembrane domains of its translated product to sequences of frizzled-l from C. elegans, Drosophila, chicken and human. We used the T31 Mouse/Hamster radiation hybrid panel to map the mouse frizzled-l to mouse chromosome 5 (5 cM from the centromere), and frizzled-9 to mouse chromosome 5 (74 cM from the centromere). (C) 2001 Elsevier Science B.V./International Society of Matrix Biology. All rights reserved.

引用

页码：147 / 151

页数：5

共 14 条

[1] CHARACTERIZATION OF THE MOUSE TYPE-X COLLAGEN GENE [J].