Poly(β-aminosulfonamides) as gene delivery vectors:: synthesis and in vitro screening

被引:4
作者
Gan, Lin [2 ,3 ]
Olson, Jennifer L. [1 ]
Ragsdale, Clifton W. [1 ]
Yu, Luping [2 ,3 ]
机构
[1] Univ Chicago, Dept Neurobiol, Chicago, IL 60637 USA
[2] Univ Chicago, Dept Chem, Chicago, IL 60637 USA
[3] Univ Chicago, James Franck Inst, Chicago, IL 60637 USA
关键词
D O I
10.1039/b714278a
中图分类号
O6 [化学];
学科分类号
0703 [化学];
摘要
A series of poly(beta-aminosulfonamides) was synthesized and demonstrated to be efficient in vitro transfection reagents.
引用
收藏
页码:573 / 575
页数:3
相关论文
共 17 条
[1]
Parallel synthesis and biophysical characterization of a degradable polymer library for gene delivery [J].
Akinc, A ;
Lynn, DM ;
Anderson, DG ;
Langer, R .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2003, 125 (18) :5316-5323
[2]
Semi-automated synthesis and screening of a large library of degradable cationic polymers for gene delivery [J].
Anderson, DG ;
Lynn, DM ;
Langer, R .
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2003, 42 (27) :3153-3158
[3]
A VERSATILE VECTOR FOR GENE AND OLIGONUCLEOTIDE TRANSFER INTO CELLS IN CULTURE AND IN-VIVO - POLYETHYLENIMINE [J].
BOUSSIF, O ;
LEZOUALCH, F ;
ZANTA, MA ;
MERGNY, MD ;
SCHERMAN, D ;
DEMENEIX, B ;
BEHR, JP .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1995, 92 (16) :7297-7301
[4]
SYNTHESIS OF TERTIARY AMINE POLYMERS [J].
DANUSSO, F ;
FERRUTI, P .
POLYMER, 1970, 11 (02) :88-&
[5]
GENE THERAPEUTICS [J].
FELGNER, PL ;
RHODES, G .
NATURE, 1991, 349 (6307) :351-352
[6]
Prevailingly cationic agmatine-based amphoteric polyamidoamine as a nontoxic, nonhemolytic, and "stealthlike" DNA complexing agent and transfection promoter [J].
Ferruti, Paolo ;
Franchini, Jacopo ;
Bencini, Marco ;
Ranucci, Elisabetta ;
Zara, Gian Paolo ;
Serpe, Loredana ;
Primo, Luca ;
Cavalli, Roberta .
BIOMACROMOLECULES, 2007, 8 (05) :1498-1504
[7]
Brighter reporter genes from multimerized fluorescent proteins [J].
Genové, G ;
Glick, BS ;
Barth, AL .
BIOTECHNIQUES, 2005, 39 (06) :814-+
[8]
Biodegradable polymeric vectors for gene delivery to human endothelial cells [J].
Green, Jordan J. ;
Shi, Julie ;
Chiu, Eugene ;
Leshchiner, Elizaveta S. ;
Langer, Robert ;
Anderson, Daniel G. .
BIOCONJUGATE CHEMISTRY, 2006, 17 (05) :1162-1169
[9]
Accelerated discovery of synthetic transfection vectors: Parallel synthesis and screening of degradable polymer library [J].
Lynn, DM ;
Anderson, DG ;
Putnam, D ;
Langer, R .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2001, 123 (33) :8155-8156
[10]
Degradable poly(β-amino esters):: Synthesis, characterization, and self-assembly with plasmid DNA [J].
Lynn, DM ;
Langer, R .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2000, 122 (44) :10761-10768