Back in the water: The return of the inositol phosphates

被引：527

作者：

Irvine, RF ^{[1
]}

Schell, MJ ^{[1
]}

机构：

[1] Univ Cambridge, Dept Pharmacol, Cambridge CB2 1QJ, England

来源：

NATURE REVIEWS MOLECULAR CELL BIOLOGY | 2001年 / 2卷 / 05期

关键词：

D O I：

10.1038/35073015

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Following the discovery of inositol-1,4,5-trisphosphate as a second messenger, many other inositol phosphates were discovered in quick succession, with some understanding of their synthesis pathways and a few guesses at their possible functions. But then it all seemed to go comparatively quiet, with an explosion of interest in the inositol lipids. Now the water-soluble phase is once again becoming a focus of interest. Old and new data point to a new vista of inositol phosphates, with functions in many diverse aspects of cell biology, such as ion-channel physiology, membrane dynamics and nuclear signalling.

引用

页码：327 / 338

页数：12

共 121 条

[61]

LOEWUS MW, 1962, PLANT PHYSIOL, V70, P1661

[62] Modulation of Ins(2,4,5)P3-stimulated Ca2+ mobilization by Ins(1,3,4,5)P4:: enhancement by activated G-proteins, and evidence for the involvement of a GAP1 protein, a putative Ins(1,3,4,5)P4 receptor [J].

Loomis-Husselbee, JW ;

Walker, CD ;

Bottomley, JR ;

Cullen, PJ ;

Irvine, RF ;

Dawson, AP .

BIOCHEMICAL JOURNAL, 1998, 331 :947-952

[63] Synergistic effects of inositol 1,3,4,5-tetrakisphosphate on inositol 2,4,5-trisphosphate-stimulated Ca2+ release do not involve direct interaction of inositol 1,3,4,5-tetrakisphosphate with inositol trisphosphate-binding sites [J].

LoomisHusselbee, JW ;

Cullen, PJ ;

Dreikhausen, UE ;

Irvine, RF ;

Dawson, AP .

BIOCHEMICAL JOURNAL, 1996, 314 :811-816

[64] INOSITOL 1,3,4,5-TETRAKISPHOSPHATE ACTIVATES AN ENDOTHELIAL CA2+-PERMEABLE CHANNEL [J].

LUCKHOFF, A ;

CLAPHAM, DE .

NATURE, 1992, 355 (6358) :356-358

[65] The role of phosphatases in inositol signaling reactions [J].

Majerus, PW ;

Kisseleva, MV ;

Norris, FA .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1999, 274 (16) :10669-10672

[66] IDENTIFICATION OF INOSITOL HEXAPHOSPHATE IN P-31-NMR SPECTRA OF DICTYOSTELIUM-DISCOIDEUM AMEBAS - RELEVANCE TO INTRACELLULAR PH DETERMINATION [J].

MARTIN, JB ;

FORAY, MF ;

KLEIN, G ;

SATRE, M .

BIOCHIMICA ET BIOPHYSICA ACTA, 1987, 931 (01) :16-25

[67]

MATTINGLY RR, 1991, J BIOL CHEM, V266, P15144

[68] MULTIPLE ISOMERS OF INOSITOL PENTAKISPHOSPHATE IN EPSTEIN-BARR-VIRUS-TRANSFORMED (T5-1) LYMPHOCYTES-B - IDENTIFICATION OF INOSITOL 1,3,4,5,6-PENTAKISPHOSPHATE, D-INOSITOL 1,2,4,5,6-PENTAKISPHOSPHATE AND L-INOSITOL 1,2,4,5,6-PENTAKISPHOSPHATE [J].

MCCONNELL, FM ;

STEPHENS, LR ;

SHEARS, SB .

BIOCHEMICAL JOURNAL, 1991, 280 :323-329

[69] Binding kinetics and ligand specificity for the interactions of the C2B domain of synaptogmin II with inositol polyphosphates and phosphoinositides [J].

Mehrotra, B ;

Myszka, DG ;

Prestwich, GD .

BIOCHEMISTRY, 2000, 39 (32) :9679-9686

[70]

MENNITI FS, 1993, J BIOL CHEM, V268, P3850

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