Transcription factors controlling the beginning and end of B-cell differentiation

被引：15

作者：

Johnson, K ^{[1
]}

Calame, K ^{[1
]}

机构：

[1] Columbia Univ, Coll Phys & Surg, Dept Microbiol, New York, NY 10032 USA

来源：

CURRENT OPINION IN GENETICS & DEVELOPMENT | 2003年 / 13卷 / 05期

关键词：

D O I：

10.1016/j.gde.2003.08.004

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Powerful techniques - including gene targeting, genomic and proteomic analyses - are allowing a more complete understanding of the transcription factors that drive B-cell development. Regulatory cascades involving multiple steps have been identified at many decision points. In addition, feedback loops and transcriptional inhibition of alternative fates have been found to be important both for commitment to the B lymphocyte lineage and for terminal B-cell differentiation.

引用

页码：522 / 528

页数：7

共 58 条

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