Chemokine receptors and chemokines in HIV infection

被引:44
作者
Garzino-Demo, A [1 ]
Devico, AL [1 ]
Gallo, RC [1 ]
机构
[1] Univ Maryland, Inst Human Virol, Ctr Med Biotechnol, Baltimore, MD 21201 USA
关键词
HIV; chemokines; chemokine receptors;
D O I
10.1023/A:1027329721892
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Suppression of HIV by chemokines represents a special case in virology and immunology where soluble molecules other than antibodies inhibit infection by a specific virus. The basis for this inhibition is that HIV has evolved to use certain chemokine receptors as "coreceptors" for entry into host cells. Human genotypes that reduce or prevent coreceptor expression are strongly associated with protection against infection and slower disease progression. We suggest that local production of certain chemokines can produce a similar modulation of coreceptor expression, and mounting evidence indicates that chemokine release is a major determinant of protection from HIV infection. Here we review this evidence and explore future avenues for investigating the role of chemokines in controlling HIV infection.
引用
收藏
页码:243 / 255
页数:13
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