Effect of Low-Intensity Aerobic Exercise on Insulin-Like Growth Factor-I and Insulin-Like Growth Factor-Binding Proteins in Healthy Men

被引:34
作者
Nishida, Yuichiro [1 ,2 ]
Matsubara, Takeshi [3 ]
Tobina, Takuro [1 ]
Shindo, Munehiro [1 ]
Tokuyama, Kumpei [4 ]
Tanaka, Keitaro [2 ]
Tanaka, Hiroaki [1 ]
机构
[1] Fukuoka Univ, Fac Hlth & Sports Sci, Exercise Physiol Lab, Fukuoka 8140180, Japan
[2] Saga Univ, Fac Med, Dept Prevent Med, Saga 8498501, Japan
[3] Lab Phys Sci Inc, Fukuoka 8100001, Japan
[4] Univ Tsukuba, Inst Hlth & Sport Sci, Lab Biochem Exercise & Nutr, Ibaraki 3058574, Japan
关键词
PROSTATE-CANCER RISK; MUSCLE IGF-I; FACTOR BINDING-PROTEIN-3; PHYSICAL-ACTIVITY; ENERGY-BALANCE; FACTOR (IGF)-I; CELL-GROWTH; LIFE-STYLE; HORMONE; DIET;
D O I
10.1155/2010/452820
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Increased concentrations of circulating insulin-like growth factor-I (IGF-I) or IGF-I relative to IGF-binding proteins (IGFBPs) are associated with increased risk of developing several forms of cancer. Conversely, exercise is linked with reduced risk. This study aims to investigate the effect of a low-intensity exercise program on circulating levels of IGF-I, IGFBP-1, and IGFBP-3, in previously sedentary males. Fourteen healthy men participated in cycle ergometer training at lactate threshold intensity for 60 min/day, 5 days/week for 6 weeks. After aerobic training, insulin sensitivity improved by 20%, while fasting insulin levels decreased by 13%. Simultaneously, low-intensity aerobic training decreased the circulating levels of IGF-I by 9%, while IGFBP-1 levels increased by 16%. An interesting finding was that higher pretraining level of IGF-I was associated with greater decline in IGF-I with training. Insulin-sensitizing low-intensity aerobic exercise is thus considered to be an effective method for downregulating IGF-I and upregulating IGFBP-1 levels.
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页数:8
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