In vivo Biodistribution and Urinary Excretion of Mesoporous Silica Nanoparticles: Effects of Particle Size and PEGylation

被引：543

作者：

He, Qianjun ^{[2
]}

Zhang, Zhiwen ^{[1
]}

Gao, Fang ^{[1
]}

Li, Yaping ^{[1
]}

Shi, Jianlin ^{[2
]}

机构：

[1] Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China

[2] Chinese Acad Sci, Shanghai Inst Ceram, State Key Lab High Performance Ceram & Superfine, Shanghai 200050, Peoples R China

来源：

SMALL | 2011年 / 7卷 / 02期

关键词：

DRUG-DELIVERY; CONTROLLED-RELEASE; HEMOLYTIC-ACTIVITY; TOXICITY; NANOMATERIALS; CYTOTOXICITY; RATS; MICE;

D O I：

10.1002/smll.201001459

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The in vivo biodistribution and urinary excretion of spherical mesoporous silica nanoparticles (MSNs) are evaluated by tail-vein injection in ICR mice, and the effects of the particle size and PEGylation are investigated. The results indicate that both MSNs and PEGylated MSNs of different particle sizes (80-360 nm) distribute mainly in the liver and spleen, a minority of them in the lungs, and a few in the kidney and heart. The PEGylated MSNs of smaller particle size escape more easily from capture by liver, spleen, and lung tissues, possess longer blood-circulation lifetime, and are more slowly biodegraded and correspondingly have a lower excreted amount of degradation products in the urine. Neither MSNs nor PEGylated MSNs cause tissue toxicity after 1 month in vivo.

引用

页码：271 / 280

页数：10

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