Polycystic ovary syndrome

被引：965

作者：

Azziz, Ricardo ^{[1
,2
]}

Carmina, Enrico ^{[3
]}

Chen, ZiJiang ^{[4
,5
]}

Dunaif, Andrea ^{[6
]}

Laven, Joop S. E. ^{[7
]}

Legro, Richard S. ^{[8
]}

Lizneva, Daria ^{[1
,9
]}

Natterson-Horowtiz, Barbara ^{[10
]}

Teede, Helena J. ^{[11
,12
]}

Yildiz, Bulent O. ^{[13
]}

机构：

[1] Augusta Univ, Dept Obstet & Gynecol, Med Coll Georgia, 1120 15th St,CB-2209, Augusta, GA 30912 USA

[2] Augusta Univ, Med Coll Georgia, Dept Med, Augusta, GA USA

[3] Univ Palermo, Dept Hlth Sci & Mother & Child Care, Palermo, Italy

[4] Shandong Univ, Shandong Prov Hosp, Ctr Reprod Med, Jinan, Peoples R China

[5] Shanghai Key Lab Assisted Reprod & Reprod Genet, Shanghai, Peoples R China

[6] Northwestern Univ, Dept Med, Feinberg Sch Med, Chicago, IL 60611 USA

[7] Erasmus MC, Div Reprod Med, Dept OBGYN, Rotterdam, Netherlands

[8] Penn State Univ, Coll Med, Dept Obstet & Gynecol, Hershey, PA USA

[9] Sci Ctr Family Hlth & Human Reprod, Dept Reprod Hlth Protect, Irkutsk, Russia

[10] Univ Calif Los Angeles, David Geffen Sch Med, Div Cardiol, Los Angeles, CA 90095 USA

[11] Monash Univ, Monash Ctr Hlth Res & Implementat, Sch Publ Hlth & Prevent Med, Clayton, Vic, Australia

[12] Monash Hlth, Clayton, Vic, Australia

[13] Hacettepe Univ, Div Endocrinol & Metab, Dept Internal Med, Sch Med, Ankara, Turkey

来源：

NATURE REVIEWS DISEASE PRIMERS | 2016年 / 2卷

关键词：

QUALITY-OF-LIFE; ANTI-MULLERIAN HORMONE; IMPAIRED GLUCOSE-TOLERANCE; FOLLICLE-STIMULATING-HORMONE; DEPENDENT DIABETES-MELLITUS; GENOME-WIDE ASSOCIATION; IN-VITRO FERTILIZATION; INTIMA-MEDIA THICKNESS; FAMILY-BASED ANALYSIS; INSULIN-RESISTANCE;

D O I：

10.1038/nrdp.2016.57

中图分类号：

R5 [内科学];

学科分类号：

100201 [内科学];

摘要：

Polycystic ovary syndrome (PCOS) affects 5-20% of women of reproductive age worldwide. The condition is characterized by hyperandrogenism, ovulatory dysfunction and polycystic ovarian morphology (PCOM)-with excessive androgen production by the ovaries being a key feature of PCOS. Metabolic dysfunction characterized by insulin resistance and compensatory hyperinsulinaemia is evident in the vast majority of affected individuals. PCOS increases the risk for type 2 diabetes mellitus, gestational diabetes and other pregnancy-related complications, venous thromboembolism, cerebrovascular and cardiovascular events and endometrial cancer. PCOS is a diagnosis of exclusion, based primarily on the presence of hyperandrogenism, ovulatory dysfunction and PCOM. Treatment should be tailored to the complaints and needs of the patient and involves targeting metabolic abnormalities through lifestyle changes, medication and potentially surgery for the prevention and management of excess weight, androgen suppression and/or blockade, endometrial protection, reproductive therapy and the detection and treatment of psychological features. This Primer summarizes the current state of knowledge regarding the epidemiology, mechanisms and pathophysiology, diagnosis, screening and prevention, management and future investigational directions of the disorder.

引用

页数：18

共 233 条

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