Absence of human herpesvirus 8 DNA sequences in neoplastic Kaposi's sarcoma cell lines

被引：41

作者：

Flamand, L

Zeman, RA

Bryant, JL

LunardiIskandar, Y

Gallo, RC

机构：

[1] UNIV MARYLAND, INST BIOTECHNOL, INST HUMAN VIROL, BALTIMORE, MD 21201 USA

[2] NCI, TUMOR CELL BIOL LAB, NIH, BETHESDA, MD 20892 USA

来源：

JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES | 1996年 / 13卷 / 02期

关键词：

Kaposi's sarcoma; HHV-8; malignancy;

D O I：

10.1097/00042560-199610010-00011

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The recent detection of herpesvirus-like DNA sequences in Kaposi's sarcoma (KS) lesions has led to numerous speculations regarding the role of this new agent in KS pathogenesis. However, recent studies indicate a far wider distribution of such viral sequences, shadowing the potential etiologic role of this agent in KS. In this report we show that malignant KS cell lines do not harbor such viral sequences while B cells, CD14(+) and CD34(+) cells do, suggesting that if a KS malignancy originates from infection with HHV-8, the virus can be lost and is not necessary for maintenance of the neoplastic state. Alternatively, HHV-8 may be a ''passenger'' in KS.

引用

页码：194 / 197

页数：4

共 29 条

[1] HERPES-LIKE SEQUENCES IN HIV-INFECTED AND UNINFECTED KAPOSIS-SARCOMA PATIENTS [J].