Structural mechanism of RNA recognition by the RIG-l-like receptors

被引：210

作者：

Yoneyama, Mitsutoshi ^{[1
,2
,3
]}

Fujita, Takashi ^{[1
,2
]}

机构：

[1] Kyoto Univ, Grad Sch Biostudies, Inst Virus Res, Mol Genet Lab, Kyoto 6068507, Japan

[2] Kyoto Univ, Grad Sch Biostudies, Mol Cell Biol Lab, Kyoto 6068507, Japan

[3] Japan Sci & Technol Agcy, PRESTO, Saitama, Japan

来源：

IMMUNITY | 2008年 / 29卷 / 02期

关键词：

D O I：

10.1016/j.immuni.2008.07.009

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Cytoplasmic nonself RNA, such as that generated by invading viruses, is recognized by a family of sensory molecules termed RIG-l-like Receptors (RLRs). Here, we discuss the mechanism of the RLRs' sensing of nonself RNA. Our findings define three functional domains of RLRs and provide insights into how RLRs function as a molecular switch through interactions with virus-specific RNA ligands.

引用

页码：178 / 181

页数：4

共 19 条

[1] Pathogen recognition and innate immunity [J].

Akira, S ;

Uematsu, S ;

Takeuchi, O .

CELL, 2006, 124 (04) :783-801

[2] The C-terminal regulatory domain is the RNA 5′-triphosphate sensor of RIG-I [J].

Cui, Sheng ;

Eisenaecher, Katharina ;

Kirchhofer, Axel ;

Brzozka, Krzysztof ;

Lammens, Alfred ;

Lammens, Katja ;

Fujita, Takashi ;

Conzelmann, Karl-Klaus ;

Krug, Anne ;

Hopfner, Karl-Peter .

MOLECULAR CELL, 2008, 29 (02) :169-179

[3] Essential role of the N-terminal domain in the regulation of RIG-I ATPase activity [J].

Gee, Peter ;

Chua, Pong Kian ;

Gevorkyan, Jirair ;

Klumpp, Klaus ;

Najera, Isabel ;

Swinney, David C. ;

Deval, Jerome .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2008, 283 (14) :9488-9496

[4] Essential role of mda-5 in type IIFN responses to polyriboinosinic: polyribocytidylic acid and encephalomyocarditis picornavirus [J].

Gitlin, Leonid ;

Barchet, Winfried ;

Gilfillan, Susan ;

Cella, Marina ;

Beutler, Bruce ;

Flavell, Richard A. ;

Diamond, Michael S. ;

Colonna, Marco .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2006, 103 (22) :8459-8464

[5] Processing of Genome 5′ Termini as a Strategy of Negative-Strand RNA Viruses to Avoid RIG-I-Dependent Interferon Induction [J].

Habjan, Matthias ;

Andersson, Ida ;

Klingstrom, Jonas ;

Schuemann, Michael ;

Martin, Arnold ;

Zimmermann, Petra ;

Wagner, Valentina ;

Pichlmair, Andreas ;

Schneider, Urs ;

Muehlberger, Elke ;

Mirazimi, Ali ;

Weber, Friedemann .

PLOS ONE, 2008, 3 (04)

[6] 5′-triphosphate RNA is the ligand for RIG-I [J].

Hornung, Veit ;

Ellegast, Jana ;

Kim, Sarah ;

Brzozka, Krzysztof ;

Jung, Andreas ;

Kato, Hiroki ;

Poeck, Hendrik ;

Akira, Shizuo ;

Conzelmann, Karl-Klaus ;

Schlee, Martin ;

Endres, Stefan ;

Hartmann, Gunther .

SCIENCE, 2006, 314 (5801) :994-997

[7] Differential roles of MDA5 and RIG-I helicases in the recognition of RNA viruses [J].

Kato, H ;

Takeuchi, O ;

Sato, S ;

Yoneyama, M ;

Yamamoto, M ;

Matsui, K ;

Uematsu, S ;

Jung, A ;

Kawai, T ;

Ishii, KJ ;

Yamaguchi, O ;

Otsu, K ;

Tsujimura, T ;

Koh, CS ;

Sousa, CRE ;

Matsuura, Y ;

Fujita, T ;

Akira, S .

NATURE, 2006, 441 (7089) :101-105

[8] Cell type-specific involvement of RIG-I in antiviral response [J].

Kato, H ;

Sato, S ;

Yoneyama, M ;

Yamamoto, M ;

Uematsu, S ;

Matsui, K ;

Tsujimura, T ;

Takeda, K ;

Fujita, T ;

Takeuchi, O ;

Akira, S .

IMMUNITY, 2005, 23 (01) :19-28

[9] Length-dependent recognition of double-stranded ribonucleic acids by retinoic acid-inducible gene-I and melanoma differentiation-associated gene 5 [J].

Kato, Hiroki ;

Takeuchi, Osamu ;

Mikamo-Satoh, Eriko ;

Hirai, Reiko ;

Kawai, Tomoji ;

Matsushita, Kazufumi ;

Hiiragi, Akane ;

Dermody, Terence S. ;

Fujita, Takashi ;

Akira, Shizuo .

JOURNAL OF EXPERIMENTAL MEDICINE, 2008, 205 (07) :1601-1610

[10] Structural basis of toll-like receptor 3 signaling with double-stranded RNA [J].

Liu, Lin ;

Botos, Istvan ;

Wang, Yan ;

Leonard, Joshua N. ;

Shiloach, Joseph ;

Segal, David M. ;

Davies, David R. .

SCIENCE, 2008, 320 (5874) :379-381

← 1 2 →