Transcriptional regulation of vascular endothelial growth factor in cancer

被引：109

作者：

Loureiro, RMB

D'Amore, PA

机构：

[1] Harvard Univ, Sch Med, Schepens Eye Res Inst, Boston, MA 02114 USA

[2] Univ N Carolina, Curriculum Genet & Mol Biol, Chapel Hill, NC 27599 USA

[3] Harvard Univ, Sch Med, Program Biol & Biomed Sci, Boston, MA 02115 USA

[4] Harvard Univ, Sch Med, Dept Ophthalmol, Boston, MA 02115 USA

[5] Harvard Univ, Sch Med, Dept Pathol, Boston, MA 02115 USA

来源：

CYTOKINE & GROWTH FACTOR REVIEWS | 2005年 / 16卷 / 01期

关键词：

VEGF; growth factors; tumors; angiogenesis; vascularization; anti-angiogenesis;

D O I：

10.1016/j.cytogfr.2005.01.005

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Vascular endothelial growth factor (VEGF) is critical for vascularization of tissues, including tumors, making it an attractive target for controlling angiogenesis. An important first step towards the goal of effectively blocking tumor angiogenesis is to understand the relationships among tumor-promoting molecules. Whereas little is known about developmental regulation of VEGF, pathological regulation of VEGF during disease states and tumorigenesis is better understood. This review focuses on transcriptional regulation of VEGF expression in cancer. Understanding how VEGF is regulated in tumors cells may provide the basis for future treatments that target both the tumor and its vascular supply. (c) 2005 Elsevier Ltd. All rights reserved.

引用

页码：77 / 89

页数：13

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