Basal forebrain neurons adjacent to the globus pallidus co-express GABAergic and cholinergic marker mRNAs

被引：56

作者：

Tkatch, T ^{[1
]}

Baranauskas, G ^{[1
]}

Surmeier, DJ ^{[1
]}

机构：

[1] Univ Tennessee, Ctr Hlth Sci, Coll Med, Dept Anat & Neurobiol, Memphis, TN 38163 USA

来源：

NEUROREPORT | 1998年 / 9卷 / 09期

关键词：

acetylcholine; basal ganglia; choline acetyltransferase; GABA; glutamate decarboxylase; single cell RT-PCR; vesicular transporter;

D O I：

10.1097/00001756-199806220-00004

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

SEMI-QUANTITATIVE single cell RT-PCR techniques were used to determine the expression of mRNAs related to GABAergic and cholinergic neurotransmission in neurons of the rat globus pallidus and adjacent basal forebrain region. Neurons of the globus pallidus expressed relatively high levels of GAD67 and GABA vesicular transporter mRNA but undetectable levels of ChAT or ACh vesicular transporter mRNA. In contrast, nominally basal forebrain neurons co-expressed ChAT and GAD67 mRNAs and mRNAs for both ACh and GABA vesicular transporters. These results suggest that the neurons along the medial border of the globus pallidus may co-release GABA and ACh. (C) 1998 Rapid Science Ltd.

引用

页码：1935 / 1939

页数：5

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