Polphyromonas gingivalis FDC381 multiplies and persists within human oral epithelial cells in vitro

被引：101

作者：

Madianos, PN

Papapanou, PN

Nannmark, U

Dahlfen, G

机构：

[1] GOTHENBURG UNIV, FAC ODONTOL, DEPT ORAL MICROBIOL, S-41390 GOTHENBURG, SWEDEN

[2] GOTHENBURG UNIV, FAC MED, DEPT ANAT & CELL BIOL, GOTHENBURG, SWEDEN

[3] AARHUS UNIV, DEPT MED MICROBIOL & IMMUNOL, AARHUS, DENMARK

来源：

INFECTION AND IMMUNITY | 1996年 / 64卷 / 02期

关键词：

D O I：

10.1128/IAI.64.2.660-664.1996

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Porphyromonas gingivalis FDC381 replication and persistence within KB epithelial cells in vitro were studied by means of an antibiotic protection assay and electron microscopy. Intracellular counts decreased during the first 24 h; showed a threefold increase during the second day, indicating intracellular multiplication; and after 8 days declined to levels approximating 40% of the initial invasion. The ability of P. gingivalis to persist and multiply within epithelial cells may constitute a pathogenic mechanism in periodontal disease.

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页码：660 / 664

页数：5

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