Epidemiology and clinical significance of Pneumocystis colonization

被引：176

作者：

Morris, Alison ^{[1
]}

Wei, Kenneth ^{[2
]}

Afshar, Kamyar ^{[2
]}

Huang, Laurence ^{[3
]}

机构：

[1] Univ Pittsburgh, Med Ctr, Sch Med, Div Pulm Allergy & Crit Care Med, Pittsburgh, PA 15213 USA

[2] Univ So Calif, Div Pulm & Crit Care Med, Los Angeles, CA USA

[3] Univ Calif San Francisco, San Francisco Gen Hosp, Div Pulm & Crit Care Med, Div HIV AIDS, San Francisco, CA USA

来源：

JOURNAL OF INFECTIOUS DISEASES | 2008年 / 197卷 / 01期

关键词：

D O I：

10.1086/523814

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Pneumocystis pneumonia has long been recognized as a cause of morbidity and mortality in immunocompromised populations, particularly those with HIV infection. Pneumocystis colonization - that is, detection of the organism or its DNA, without signs or symptoms of pneumonia - has recently been described, and accumulating evidence suggests that it may be an important clinical phenomenon. Sensitive molecular techniques such as polymerase chain reaction are frequently used to identify Pneumocystis colonization. Low levels of Pneumocystis in the lungs may stimulate pulmonary inflammation and may play a role in the development of lung diseases such as chronic obstructive pulmonary disease. In this review, we discuss evidence for the occurrence of Pneumocystis colonization in animals as well as the epidemiology and risk factors for Pneumocystis colonization in various human populations. We also evaluate the clinical significance of Pneumocystis colonization and its relationship to lung disease.

引用

页码：10 / 17

页数：8