Peroxisome Proliferator-Activated Receptors and Hepatitis C Virus-Induced Insulin Resistance

被引：13

作者：

Negro, Francesco ^{[1
]}

机构：

[1] Univ Geneva, Viropathol Unit, Med Ctr, CH-1211 Geneva, Switzerland

来源：

PPAR RESEARCH | 2009年 / 2009卷

基金：

瑞士国家科学基金会;

关键词：

PPAR-GAMMA; ANTIVIRAL THERAPY; LOW-DENSITY; ALPHA; EXPRESSION; FIBROSIS; GLUCOSE; PIOGLITAZONE; LIVER; CHOLESTEROL;

D O I：

10.1155/2009/483485

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Insulin resistance and type 2 diabetes are associated with hepatitis C virus infection. A wealth of clinical and experimental data suggests that the virus is directly interfering with the insulin signalling in hepatocytes. In the case of at least one viral genotype (the type 3a), insulin resistance seems to be directly mediated by the downregulation of the peroxisome proliferator-activated receptor gamma. Whether and how this interaction may be manipulated pharmacologically, in order to improve the responsiveness to antivirals of insulin resistant chronic hepatitis C, patients remain to be fully explored. Copyright (C) 2009 Francesco Negro.

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页数：6

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