A preliminary study of medial temporal lobe function in youths with a history of caregiver deprivation and emotional neglect

被引：157

作者：

Maheu, Francoise S. ^{[1
,2
]}

Dozier, Mary ^{[3
]}

Guyer, Amanda E. ^{[4
]}

Mandell, Darcy ^{[4
]}

Peloso, Elizabeth ^{[3
]}

Poeth, Kaitlin ^{[4
]}

Jenness, Jessica ^{[4
]}

Lau, Jennifer Y. F. ^{[5
]}

Ackerman, John P. ^{[6
]}

Pine, Daniel S. ^{[4
]}

Ernst, Monique ^{[4
]}

机构：

[1] CHU Ste Justine, Res Ctr, Montreal, PQ H3T 1C5, Canada

[2] Univ Montreal, Dept Psychiat, Fac Med, Montreal, PQ H3T 1C5, Canada

[3] Univ Delaware, Newark, DE USA

[4] NIMH, Bethesda, MD 20892 USA

[5] Univ Oxford, Oxford, England

[6] Univ Maryland, Sch Med, Baltimore, MD 21201 USA

来源：

COGNITIVE AFFECTIVE & BEHAVIORAL NEUROSCIENCE | 2010年 / 10卷 / 01期

关键词：

POSTTRAUMATIC-STRESS-DISORDER; CHILDHOOD SEXUAL-ABUSE; EARLY INSTITUTIONAL DEPRIVATION; PREFRONTAL CORTEX ACTIVATION; MALTREATED CHILDREN; DEVELOPMENTAL EXAMINATION; INTERNATIONAL ADOPTION; AMYGDALA RESPONSE; BRAIN ENGAGEMENT; ANGRY FACES;

D O I：

10.3758/CABN.10.1.34

中图分类号：

B84 [心理学]; C [社会科学总论]; Q98 [人类学];

学科分类号：

03 ; 0303 ; 030303 ; 04 ; 0402 ;

摘要：

Previous research findings have linked caregiver deprivation and emotional neglect with sensitivity to threatening cues. The present preliminary study investigated whether dysfunctions of the medial temporal lobe could underlie these associations. Using fMRI, we measured medial temporal lobe responses to emotional faces (angry, fearful, happy, neutral) among 30 youths. Eleven of the youths had a history of caregiver deprivation and emotional neglect. Attention states (i.e., attention to anger, fear, or physical attributes, or passive viewing) were systematically manipulated. Relative to comparison youths, youths with a history of caregiver deprivation and emotional neglect showed significantly greater left amygdala and left anterior hippocampus activation during the processing of threatening information. To our knowledge, these findings are the first to demonstrate altered medial temporal lobe function during the processing of threat cues in youths with a history of caregiver deprivation and emotional neglect.

引用

页码：34 / 49

页数：16

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