Growth and drug resistance phenotypes resulting from cytomegalovirus DNA polymerase region III mutations observed in clinical specimens

被引：47

作者：

Chou, Sunwen

Marousek, Gail I.

Van Wechel, Laura C.

Li, Shaobing

Weinberg, Adriana

机构：

[1] VA Med Ctr, Portland, OR USA

[2] Oregon Hlth & Sci Univ, Div Infect Dis, Portland, OR 97201 USA

[3] Univ Colorado, Hlth Sci Ctr, Div Infect Dis, Denver, CO USA

[4] Univ Colorado, Hlth Sci Ctr, Div Pediat Infect Dis, Denver, CO USA

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2007年 / 51卷 / 11期

关键词：

D O I：

10.1128/AAC.00736-07

中图分类号：

Q93 [微生物学];

学科分类号：

071005 [微生物学]; 100705 [微生物与生化药学];

摘要：

Recombinant phenotyping of cytomegalovirus (CMV) pol region III mutations from clinical specimens showed that T813S and G841A each conferred foscarnet resistance and approximately threefold increased ganciclovir resistance; adding the UL97 mutation C592G increased ganciclovir resistance to approximately sixfold. Bacterial artificial chromosome CMV clones containing pol mutation L845P were nonviable unless repaired with the wild-type sequence.

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收藏

页码：4160 / 4162

页数：3

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