Improving calibration accuracy in gel dosimetry

被引:84
作者
Oldham, M
McJury, M
Baustert, IB
Webb, S
Leach, MO
机构
[1] Inst Canc Res, Joint Dept Phys, Sutton SM2 5PT, Surrey, England
[2] Royal Marsden NHS Trust, Sutton SM2 5PT, Surrey, England
[3] Canc Res Inst, CRC, Clin MR Res Grp, Sutton SM2 5PT, Surrey, England
关键词
D O I
10.1088/0031-9155/43/10/002
中图分类号
R318 [生物医学工程];
学科分类号
0831 ;
摘要
A new method of calibrating gel dosimeters (applicable to both Fricke and polyacrylamide gels) is presented which has intrinsically higher accuracy than current methods, and requires less gel. Two test-tubes of gel (inner diameter 2.5 cm, length 20 cm) are irradiated separately with a 10 x 10 cm(2) field end-on in a water bath, such that the characteristic depth-dose curve is recorded in the gel. The calibration is then determined by fitting the depth-dose measured in water, against the measured change in relaxivity with depth in the gel. Increased accuracy is achieved in this simple depth-dose geometry by averaging the relaxivity at each depth. A large number of calibration data points, each with relatively high accuracy, are obtained. Calibration data over the full range of dose (1.6-10 Gy) is obtained by irradiating one test-tube to 10 Gy at dose maximum (D-max), and the other to 4.5 Gy at D-max. The new calibration method is compared with a 'standard method' where five identical test-tubes of gel were irradiated to different known doses between 2 and 10 Gy, The percentage uncertainties in the slope and intercept of the calibration fit are found to be lower with the new method by a factor of about 4 and 10 respectively, when compared with the standard method and with published values. The gel was found to respond linearly within the error bars up to doses of 7 Gy, with a slope of 0.233 +/- 0.001 s(-1) Gy(-1) and an intercept of 1.106 +/- 0.005 Gy. For higher doses, nonlinear behaviour was observed.
引用
收藏
页码:2709 / 2720
页数:12
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