Analysis of CD4+CD25+ cell population in the thymus from myasthenia gravis patients

被引：11

作者：

Balandina, A ^{[1
]}

Saoudi, A

Dartevelle, P

Berrih-Aknin, S

机构：

[1] Univ Paris 11, Hop Marie Lannelongue, IPSC,UMR 8078, CNRS, F-92350 Le Plessis Robinson, France

[2] Hop Purpan, INSERM, U 28, Toulouse, France

[3] Hop Marie Lannelongue, Serv Chirurg Thorac, F-92350 Le Plessis Robinson, France

来源：

MYASTHENIA GRAVIS AND RELATED DISORDERS: BIOMCHEMICAL BASIS FOR DISEASE OF THE NEUROMUSCULAR JUNCTION | 2003年 / 998卷

关键词：

CD4(+)CD25(+) T cells; myasthenia gravis; thymus; thymocyte population;

D O I：

10.1196/annals.1254.030

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The present study is aimed at exploring the regulatory CD4(+)CD25(+) T cells in the thymus from myasthenia gravis (MG) patients. In early-onset MG, the thymus is hyperplastic and contains autoreactive activated T cells. Preliminary studies indicate that these CD4(+)CD25(+) cells include activated autoreactive T cells. Studies to characterize the phenotype and suppressive capacity of these cells will be discussed.

引用

页码：275 / 277

页数：3

共 5 条

[1] LEPRINCE C, 1990, J IMMUNOL, V145, P2115
[2] Thymocyte Fas expression is dysregulated in Myasthenia gravis patients with anti-acetylcholine receptor antibody
Moulian, N
Bidault, J
Truffault, F
Yamamoto, AM
Levasseur, P
Berrih-Aknin, S
[J]. BLOOD, 1997, 89 (09) : 3287 - 3295
[3] CD4+CD25+ suppressor T cells:: More questions than answers
Shevach, EM
[J]. NATURE REVIEWS IMMUNOLOGY, 2002, 2 (06) : 389 - 400
[4] Stephens LA, 2001, EUR J IMMUNOL, V31, P1247, DOI 10.1002/1521-4141(200104)31:4<1247::AID-IMMU1247>3.0.CO
[5] 2-M

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