Increased arterial intima-media thickness and in vivo LDL oxidation in young men with borderline hypertension

被引:130
作者
Toikka, JO
Laine, H
Ahotupa, M
Haapanen, A
Viikari, JSA
Hartiala, JJ
Raitakari, OT
机构
[1] Turku Univ, Turku PET Ctr, FIN-20520 Turku, Finland
[2] Turku Univ, MCA Res Lab, FIN-20520 Turku, Finland
[3] Turku Univ Hosp, Dept Clin Physiol, FIN-20520 Turku, Finland
[4] Turku Univ Hosp, Dept Med, FIN-20520 Turku, Finland
[5] Turku Univ Hosp, Dept Radiol, FIN-20520 Turku, Finland
关键词
hypertension; borderline; oxidized LDL; intima-media thickness;
D O I
10.1161/01.HYP.36.6.929
中图分类号
R6 [外科学];
学科分类号
1002 ; 100210 ;
摘要
We used borderline hypertension as a model for prehypertension to examine the early influences of elevated blood pressure on subclinical atherosclerosis, lipoprotein oxidation, and cardiac adaptation. Healthy men (age 37+/-4 years) were classified prospectively into 2 groups on the basis of having either borderline hypertension (systolic 130 to 140 mm Hg or diastolic 85 to 89 mm Hg, n=16) or normal (<130/85 mm Hg, n=22) blood pressure values during the previous 2 years. The groups were matched for age, body size, and serum cholesterol levels. High-resolution ultrasound was used to measure intima-media thickness (IMT) of the carotid and brachial arteries, cardiac dimensions, and brachial artery endothelial function. Baseline low-density lipoprotein (LDL)-diene conjugation was measured as an estimate of in vivo LDL oxidation (ox-LDL). Compared with normotensive controls, men with borderline hypertension had higher IMT of the carotid artery (0.58+/-0.06 versus 0.75+/-0.07 mm, P<0.001) and IMT of the brachial artery (0.45+/-0.05 versus 0.57+/-0.07 mm, P<0.001), and increased levels of ox-LDL (29+/-9 Versus 47+/-17 mol/L, P<0.001), but similar endothelial function. Left ventricular mass was similar in both groups, but there were significant differences in left ventricular geometry. In multivariate analyses, the predictors of carotid IMT were 24-hour systolic blood pressure (P<0.001) and ox-LDL (P=0.10). The current study demonstrates evidence of increased subclinical atherosclerosis and ox-LDL in borderline hypertension. These results are consistent with the idea that enhanced ox-LDL may be one of the pathophysiological events related to development of atherosclerosis in men with borderline elevated blood pressure.
引用
收藏
页码:929 / 933
页数:5
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