Innate immune defense against malaria infection in the mosquito

被引:104
作者
Dimopoulos, G [1 ]
Müller, HM [1 ]
Levashina, EA [1 ]
Kafatos, FC [1 ]
机构
[1] European Mol Biol Lab, D-69117 Heidelberg, Germany
基金
美国国家卫生研究院;
关键词
D O I
10.1016/S0952-7915(00)00186-2
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Anopheles gambiae, the most important vector of malaria, employs its innate immune system in the light against Plasmodium. This can affect the propagative capacity of Plasmodium in the vector and, in some cases, leads to total refractoriness to the parasite. The components operating in the mosquito's innate immune system and their potential relevance to antimalarial responses are being systematically dissected.
引用
收藏
页码:79 / 88
页数:10
相关论文
共 72 条
[1]   Mechanisms of phagocytosis in macrophages [J].
Aderem, A ;
Underhill, DM .
ANNUAL REVIEW OF IMMUNOLOGY, 1999, 17 :593-623
[2]   Anopheles gambiae Ag-STAT, a new insect member of the STAT family, is activated in response to bacterial infection [J].
Barillas-Mury, C ;
Han, YS ;
Seeley, D ;
Kafatos, FC .
EMBO JOURNAL, 1999, 18 (04) :959-967
[3]   Immune factor Gambif1, a new rel family member from the human malaria vector, Anopheles gambiae [J].
BarillasMury, C ;
Charlesworth, A ;
Gross, I ;
Richman, A ;
Hoffmann, JA ;
Kafatos, FC .
EMBO JOURNAL, 1996, 15 (17) :4691-4701
[4]   Genetics of mosquito vector competence [J].
Beerntsen, BT ;
James, AA ;
Christensen, BM .
MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS, 2000, 64 (01) :115-+
[5]   Malaria parasite development in mosquitoes [J].
Beier, JC .
ANNUAL REVIEW OF ENTOMOLOGY, 1998, 43 :519-543
[6]   Identification and cloning of a glucan- and liopoplysaccharide-binding protein from Eisenia foetida earthworm involved in the activation of prophenoloxidase cascade [J].
Beschin, A ;
Bilej, M ;
Hanssens, F ;
Raymakers, J ;
Van Dyck, E ;
Revets, H ;
Brys, L ;
Gomez, J ;
De Baetselier, P ;
Timmermans, M .
JOURNAL OF BIOLOGICAL CHEMISTRY, 1998, 273 (38) :24948-24954
[7]   Stable germline transformation of the malaria mosquito Anopheles stephensi [J].
Catteruccia, F ;
Nolan, T ;
Loukeris, TG ;
Blass, C ;
Savakis, C ;
Kafatos, FC ;
Crisanti, A .
NATURE, 2000, 405 (6789) :959-962
[8]   Toward Anopheles transformation:: Minos element activity in anopheline cells and embryos [J].
Catteruccia, F ;
Nolan, T ;
Blass, C ;
Müller, HM ;
Crisanti, A ;
Kafatos, FC ;
Loukeris, TG .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2000, 97 (05) :2157-2162
[9]   Identification, purification and properties of a β-1,3-glucan-specific lectin from the serum of the cockroach, Blaberus discoidalis which is implicated in immune defence reactions [J].
Chen, CL ;
Rowley, AF ;
Newton, RP ;
Ratcliffe, NA .
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY B-BIOCHEMISTRY & MOLECULAR BIOLOGY, 1999, 122 (03) :309-319
[10]   THE INDUCIBLE ANTIBACTERIAL PEPTIDES OF INSECTS [J].
COCIANCICH, S ;
BULET, P ;
HETRU, C ;
HOFFMANN, JA .
PARASITOLOGY TODAY, 1994, 10 (04) :132-139