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Chromatin remodelling and epigenetic features of germ cells

被引：331
作者：
Kimmins, S [1 ]
Sassone-Corsi, P [1 ]
机构：
[1] Inst Genet & Biol Mol & Cellulaire, F-67404 Strasbourg, France
来源：
NATURE | 2005年 / 434卷 / 7033期
关键词：
D O I：
10.1038/nature03368
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Germ cells have the unique capacity to start a new life upon fertilization. They are generated during a sex-specific differentiation programme called gametogenesis. Maturation of germ cells is characterized by an impressive degree of cellular restructuring and gene regulation that involves remarkable genomic reorganization. These events are finely tuned, but are also susceptible to the introduction of various types of error. Because stable genetic transmission to future generations is essential for life, understanding the control of these processes has far-reaching implications for human health and reproduction.
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页码：583 / 589
页数：7
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