The response of mammalian cells to double-stranded RNA

被引：187

作者：

Gantier, Michael P. ^{[1
]}

Williams, Bryan R. G. ^{[1
]}

机构：

[1] Monash Med Ctr, Inst Med Res, Clayton, Vic 3168, Australia

来源：

CYTOKINE & GROWTH FACTOR REVIEWS | 2007年 / 18卷 / 5-6期

关键词：

double-stranded RNA; RNA interference; innate immunity;

D O I：

10.1016/j.cytogfr.2007.06.016

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Double-stranded RNA (dsRNA) has long been recognized as a central component of the interferon (IFN) system. It was originally characterized as a key mediator of IFN induction in response to virus infection. Subsequently, it was identified as a prime activator of the antiviral response. In recent years the discovery of the RNA interference (RNAi) pathway in mammals has renewed interest in dsRNA-mediated cellular responses. This has coincided with the identification of key components of the IFN induction pathway. Here, we present an overview of the current knowledge of dsRNA-mediated pathways in mammalian cells and introduce a link between these pathways and application of RNAi. (c) 2007 Elsevier Ltd. All rights reserved.

引用

页码：363 / 371

页数：9

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