Finding genes for SLE:: complex interactions and complex populations

被引：10

作者：

Alarcón-Riquelme, ME ^{[1
]}

Prokunina, L ^{[1
]}

机构：

[1] Uppsala Univ, Rudbeck Lab, Dept Genet & Pathol, Unit Med Genet, S-75185 Uppsala, Sweden

来源：

JOURNAL OF AUTOIMMUNITY | 2003年 / 21卷 / 02期

关键词：

D O I：

10.1016/S0896-8411(03)00093-3

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 [免疫学];

摘要：

Many years of work, multiplex family collection and endless genotyping finally give fruit. The original aim cannot be lost. The aim is not only to identify mutations involved in susceptibility for systemic lupus erythematosus (SLE) but to elucidate the disease pathogenesis as well. After genetics comes the biology. We review our recent findings on the genetics of lupus, provide possible mechanisms for disease susceptibility and present some facts on the problematic of identifying susceptibility mutations for complex diseases in complex human populations. (C) 2003 Elsevier Ltd. All rights reserved.

引用

页码：117 / 120

页数：4

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