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T cell differentiation: a mechanistic view

被引：66
作者：
Avni, O
Rao, A
机构：
[1] Harvard Univ, Sch Med, Dept Pathol, Boston, MA 02115 USA
[2] Ctr Blood Res, Boston, MA 02115 USA
来源：
CURRENT OPINION IN IMMUNOLOGY | 2000年 / 12卷 / 06期
关键词：
D O I：
10.1016/S0952-7915(00)00158-8
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
It has recently become clear that cytokine expression by T cells involves epigenetic changes in chromatin structure, locus accessibility and DNA methylation that occur during differentiation of naive T cells into mature effector T cells. These changes require the coordinate actions of antigen- and cytokine-induced transcription factors, chromatin remodeling complexes, histone-modifying enzymes and subset-specific transcription factors.
引用
收藏
页码：654 / 659
页数：6
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