Targeting survival: Integration site selection by retroviruses and LTR-retrotransposons

被引：164

作者：

Bushman, FD ^{[1
]}

机构：

[1] Salk Inst Biol Studies, Infect Dis Lab, La Jolla, CA 92037 USA

来源：

CELL | 2003年 / 115卷 / 02期

关键词：

D O I：

10.1016/S0092-8674(03)00760-8

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 [生物化学与分子生物学]; 081704 [应用化学];

摘要：

Replication of retroviruses and retrotransposons depends on selecting a favorable chromosomal site for integration of their genomic DNA. Different retroelements; meet this challenge by targeting distinctive chromosomal regions. Despite these differences, recent data hints at a common targeting mechanism-tethering of integration complexes to proteins bound at favorable sites.

引用

页码：135 / 138

页数：4

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