DNA torsional stress propagates through chromatin fiber and participates in transcriptional regulation

被引：39

作者：

Lavelle, Christophe ^{[1
]}

机构：

[1] Inst Curie, CNRS, UMR 168, Lab Physicochim Curie, F-75231 Paris 05, France

来源：

NATURE STRUCTURAL & MOLECULAR BIOLOGY | 2008年 / 15卷 / 02期

关键词：

D O I：

10.1038/nsmb0208-123

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Transient mechanical stresses induced by molecular motors that move DNA can propagate through the chromatin fiber and trigger local DNA alterations that in turn allow for specific DNA-protein interactions. Hence, DNA supercoiling modulations and chromatin conformational dynamics concur in gene regulation.

引用

页码：123 / 125

页数：4

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