Giant proteins that move DNA:: bullies of the genomic playground

被引：43

作者：

Cozzarelli, Nicholas R. ^{[1
]}

Cost, Gregory J. ^{[1
]}

Nöllmann, Marcelo ^{[1
]}

Viard, Thierry ^{[1
]}

Stray, James E. ^{[1
]}

机构：

[1] Univ Calif Berkeley, Dept Mol & Cell Biol, Berkeley, CA 94720 USA

来源：

NATURE REVIEWS MOLECULAR CELL BIOLOGY | 2006年 / 7卷 / 08期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1038/nrm1982

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

As genetic material DNA is wonderful, but as a macromolecule it is unruly, voluminous and fragile. Without the action of DNA replicases, topoisomerases, helicases, translocases and recombinases, the genome would collapse into a topologically entangled random coil that would be useless to the cell. We discuss the organization, movement and energetics of these proteins that are crucial to the preservation of a molecule that has such beautiful biological but challenging physical properties.

引用

页码：580 / 588

页数：9

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