Global and regional cardiac function in lifelong endurance athletes with and without myocardial fibrosis

被引:15
作者
Eijsvogels, Thijs M. H. [1 ,2 ]
Oxborough, David L. [1 ]
O'Hanlon, Rory [3 ,4 ]
Sharma, Sanjay [5 ]
Prasad, Sanjay [6 ]
Whyte, Greg [1 ]
George, Keith P. [1 ]
Wilson, Mathew G. [7 ]
机构
[1] Liverpool John Moores Univ, Res Inst Sports & Exercise Sci, Byrom St,Tom Reilly Bldg, Liverpool L3 3AF, Merseyside, England
[2] Radboud Univ Nijmegen, Dept Physiol, Med Ctr, Nijmegen, Netherlands
[3] St Vincents Univ Hosp, Dublin, Ireland
[4] Blackrock Clin, Dublin, Ireland
[5] St George Hosp, Dept Heart Muscle Disorders & Sports Cardiol, London, England
[6] Royal Brompton & Harefield NHS Trust, Dept Cardiac Magnet Resonance Imaging, London, England
[7] Qatar Orthopaed & Sports Med Hosp, ASPETAR, Doha, Qatar
基金
欧盟地平线“2020”;
关键词
Exercise; cardiac remodelling; echocardiography; late gadolinium enhancement; MAGNETIC-RESONANCE; PROGNOSTIC RELEVANCE; MARATHON RUNNERS; PREVALENCE; EXERCISE; DISEASE; RISK; METAANALYSIS; INFARCTION; EVENTS;
D O I
10.1080/17461391.2017.1373864
中图分类号
G8 [体育];
学科分类号
040301 [体育人文社会学];
摘要
The aim of the present study was to compare cardiac structure as well as global and regional cardiac function in athletes with and without myocardial fibrosis (MF). Cardiac magnetic resonance imaging with late gadolinium enhancement was used to detect MF and global cardiac structure in nine lifelong veteran endurance athletes (58 +/- 5 years, 43 +/- 5 years of training). Transthoracic echocardiography using tissue-Doppler and myocardial strain imaging assessed global and regional (18 segments) longitudinal left ventricular function. MF was present in four athletes (range 1-8g) and not present in five athletes. MF was located near the insertion points of the right ventricular free wall on the left ventricle in three athletes and in the epicardial lateral wall in one athlete. Athletes with MF demonstrated a larger end diastolic volume (205 +/- 24 vs 173 +/- 18ml) and posterior wall thickness (11 +/- 1 vs 9 +/- 1mm) compared to those without MF. The presence of MF did not mediate global tissue velocities or global longitudinal strain and strain rate; however, regional analysis of longitudinal strain demonstrated reduced function in some fibrotic regions. Furthermore, base to apex gradient was affected in three out of four athletes with MF. Lifelong veteran endurance athletes with MF demonstrate larger cardiac dimensions and normal global cardiac function. Fibrotic areas may demonstrate some co-localised regional cardiac dysfunction, evidenced by an affected cardiac strain and base to apex gradient. These data emphasize the heterogeneous phenotype of MF in athletes.
引用
收藏
页码:1297 / 1303
页数:7
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