Brief review: Glucocorticoid excretion in obesity

被引：27

作者：

Muessig, Karsten ^{[1
]}

Remer, Thomas ^{[2
]}

Maser-Gluth, Christiane ^{[3
]}

机构：

[1] Univ Tubingen Hosp, Dept Internal Med, Div Endocrinol Diabetol Angiol Nephrol & Clin Che, Tubingen, Germany

[2] Res Inst Child Nutr, Dept Nutr & Hlth, Dortmund, Germany

[3] Heidelberg Univ, Dept Pharmacol, Steroid Lab, D-6900 Heidelberg, Germany

来源：

JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY | 2010年 / 121卷 / 3-5期

关键词：

Urinary free cortisone; Urinary free cortisol; UFF; UFE; 11 beta-Hydroxysteroid dehydrogenase type 1; 11 beta-Hydroxysteroid dehydrogenase type 2; Hypothalamic-pituitary-adrenal axis; Urine volume; 11-BETA-HYDROXYSTEROID DEHYDROGENASE TYPE-1; BODY-FAT DISTRIBUTION; URINARY FREE CORTISOL; PITUITARY-ADRENAL AXIS; ADIPOSE-TISSUE; METABOLIC SYNDROME; VISCERAL OBESITY; HEALTHY-CHILDREN; HYDROXYSTEROID DEHYDROGENASE; ADRENOCORTICAL FUNCTION;

D O I：

10.1016/j.jsbmb.2010.01.008

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Cortisol secretion and glucocorticoid excretion rates are regularly increased in obesity and associate with indices of body size and visceral adiposity. Different mechanisms may underlie the elevated urinary excretion rates of cortisol metabolites in obesity. In the present brief overview, potential mechanisms are discussed, paying special attention to cortisol metabolism. Besides, potential confounding factors in the evaluation of urinary glucocorticoid excretion are highlighted. (C) 2010 Elsevier Ltd. All rights reserved.

引用

页码：589 / 593

页数：5

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