Endoplasmic reticulum is missing in dendritic spines of Purkinje cells of the ataxic mutant rat

被引：81

作者：

DekkerOhno, K

Hayasaka, S

Takagishi, Y

Oda, S

Wakasugi, N

Mikoshiba, K

Inouye, M

Yamamura, H

机构：

[1] NAGOYA UNIV,ENVIRONM MED RES INST,NAGOYA,AICHI 46401,JAPAN

[2] UNIV TOKYO,INST MED SCI,DEPT MOLEC NEUROBIOL,MINATO KU,TOKYO 108,JAPAN

来源：

BRAIN RESEARCH | 1996年 / 714卷 / 1-2期

关键词：

autosomal recessive; ataxic mutant; dilute-opisthotonus rat; dendritic spine; endoplasmic reticulum; inositol 1,4,5-trisphosphate receptor; Purkinje cell abnormality;

D O I：

10.1016/0006-8993(95)01560-4

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Dilute-opisthotonus (dop) is a spontaneous ataxic mutation in the rat, regulated by an autosomal recessive gene. Immunohistochemical staining with anti-inositol 1,4,5-trisphosphate receptor antibody and electron microscopic examinations revealed that the endoplasmic reticulum in dendritic spines of Purkinje cell was missing in the ataxic rat. This could impair the intracellular signal transduction in the parallel fiber-Purkinje cell synapse, and be a cause of the seven ataxic movement.

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收藏

页码：226 / 230

页数：5

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