Predominance of an ST11 extended-spectrum β-lactamase-producing Klebsiella pneumoniae clone causing bacteraemia and urinary tract infections in Korea

被引：60

作者：

Ko, Kwan Soo ^{[1
,2
]}

Lee, Ji-Young ^{[1
]}

Baek, Jin Yang ^{[2
]}

Suh, Ji-Yoeun ^{[2
]}

Lee, Mi Young ^{[2
]}

Choi, Ji Young ^{[1
]}

Yeom, Joon-Sup ^{[3
]}

Kim, Yeon-Sook ^{[4
]}

Jung, Sook-In ^{[5
]}

Shin, Sang Yop ^{[6
]}

Heo, Sang Taek ^{[7
,8
]}

Kwon, Ki Tae ^{[9
]}

Son, Jun Seong ^{[10
]}

Kim, Shin-Woo ^{[11
]}

Chang, Hyun-Ha ^{[11
]}

Ki, Hyun Kyun ^{[12
]}

Chung, Doo Ryeon ^{[13
]}

Peck, Kyong Ran ^{[13
]}

Song, Jae-Hoon ^{[2
,13
]}

机构：

[1] Sungkyunkwan Univ, Sch Med, Dept Mol Cell Biol, Suwon 440746, South Korea

[2] Asian Pacific Res Fdn Infect Dis ARFID, Seoul 135710, South Korea

[3] Sungkyunkwan Univ, Dept Internal Med, Kangbuk Samung Hosp, Sch Med, Seoul 110746, South Korea

[4] Chungnam Natl Univ Hosp, Taejon 301721, South Korea

[5] Chonnam Natl Univ, Sch Med, Div Infect Dis, Kwangju 501757, South Korea

[6] Cheju Natl Univ, Sch Med, Jeju Natl Univ Hosp, Cheju 690716, South Korea

[7] Gyeongsang Natl Univ, Sch Med, Dept Internal Med, Cheju 660702, South Korea

[8] Gyeongsang Inst Hlth Sci, Cheju 660702, South Korea

[9] Daegu Fatima Hosp, Taegu 701600, South Korea

[10] Kyung Hee Univ, EW Neo Med Ctr, Seoul 134727, South Korea

[11] Kyungpook Natl Univ Hosp, Taegu 700721, South Korea

[12] Konkuk Univ Hosp, Seoul 143729, South Korea

[13] Sungkyunkwan Univ, Sch Med, Div Infect Dis, Samsung Med Ctr, Seoul 135710, South Korea

来源：

JOURNAL OF MEDICAL MICROBIOLOGY | 2010年 / 59卷 / 07期

关键词：

ESCHERICHIA-COLI; CTX-M; MOLECULAR EPIDEMIOLOGY; DISSEMINATION; PREVALENCE; EMERGENCE; STRAINS; SHV-12; IDENTIFICATION; HOSPITALS;

D O I：

10.1099/jmm.0.018119-0

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

fTo investigate the antimicrobial resistance, extended-spectrum beta-lactamases (ESBLs) and clones of Klebsiella pneumoniae isolates causing bacteraemia or urinary tract infection (UTI) in Korea, a total of 406 K. pneumoniae isolates from patients with bacteraemia (221 isolates) and UTI (185 isolates) were collected from 10 tertiary-care Korean hospitals from July 2006 to October 2007. In vitro antimicrobial susceptibility testing was performed for all isolates and ESBL production was tested. Multi locus sequence typing (MLST) analyses were performed to characterize genotypes of ESBL-producing K. pneumoniae isolates. PFGE was performed for sequence type 11 (ST11) isolates. Forty-seven UTI isolates (25.4%) produced ESBLs, while 30 bacteraemia isolates (13.6%) produced ESBLs (P=0.002). Among 77 ESBL-producing isolates, thirty-two (41.6%) produced SHV-type ESBLs. bla(CTX-M) genes such as bla(CTX-M-14) and bla(CTX-M-15) were detected in 36.4%. MLST and PFGE analyses showed that ST11 was dominant in ESBL-producing K. pneumoniae isolates causing UTI (57.4%) and in those causing bacteraemia (70.0%) and has been prevalent in Korean hospitals. ST11 isolates harbour a combination of different ESBL genes. The ST11 clone of ESBL-producing K pneumoniae isolates prevails in Korea, but most isolates might acquire ESBL genes independently or several different clones might be distributed in Korea.

引用

页码：822 / 828

页数：7

共 21 条

[1] Genetic characterisation of CTX-M-15-producing Klebsiella pneumoniae and Escherichia coli strains isolated from stem cell transplant patients in Tunisia [J].

Abbassi, Mohamed Salah ;

Torres, Carmen ;

Achour, Wafa ;

Vinue, Laura ;

Saenz, Yolanda ;

Costa, Daniela ;

Bouchami, Ons ;

Ben Hassen, Assia .

INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS, 2008, 32 (04) :308-314

[2] High prevalence of SHV-12 and the emergence of CTX-M-12 in clinical isolates of Klebsiella pneumoniae from Korea [J].

Bae, Il Kwon ;

Lee, You-Nae ;

Jeong, Seok Hoon ;

Lee, Kyungwon ;

Lee, Hyukmin ;

Kwak, Hyo-Sun ;

Woo, Gun-Jo .

INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS, 2007, 29 (03) :362-364

[3] Virulent Clones of Klebsiella pneumoniae: Identification and Evolutionary Scenario Based on Genomic and Phenotypic Characterization [J].

Brisse, Sylvain ;

Fevre, Cindy ;

Passet, Virginie ;

Issenhuth-Jeanjean, Sylvie ;

Tournebize, Regis ;

Diancourt, Laure ;

Grimont, Patrick .

PLOS ONE, 2009, 4 (03)

[4] Evidence for Clonal Dissemination of the Serotype K1 Klebsiella pneumoniae Strain Causing Invasive Liver Abscesses in Korea [J].

Chung, Doo Ryeon ;

Lee, Ha Rim ;

Lee, Seung Soon ;

Kim, Shin Woo ;

Chang, Hyun-Ha ;

Jung, Sook-In ;

Oh, Myoung-don ;

Ko, Kwan Soo ;

Kang, Cheol-In ;

Peck, Kyong Ran ;

Song, Jae-Hoon .

JOURNAL OF CLINICAL MICROBIOLOGY, 2008, 46 (12) :4061-4063

[5] Expansion and countrywide dissemination of ST11, ST15 and ST147 ciprofloxacin-resistant CTX-M-15-type β-lactamase-producing Klebsiella pneumoniae epidemic clones in Hungary in 2005 -: the new 'MRSAs'? [J].

Damjanova, Ivelina ;

Toth, Akos ;

Paszti, Judit ;

Hajbel-Vekony, Gabriella ;

Jakab, Melinda ;

Berta, Judit ;

Milch, Hedda ;

Fuezi, Miklos .

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 2008, 62 (05) :978-985

[6] Multilocus sequence typing of Klebsiella pneumoniae nosocomial isolates [J].

Diancourt, L ;

Passet, V ;

Verhoef, J ;

Grimont, PAD ;

Brisse, S .

JOURNAL OF CLINICAL MICROBIOLOGY, 2005, 43 (08) :4178-4182

[7] Molecular epidemiology of extended-spectrum β-lactamase-producing Klebsiella pneumoniae strains in a university hospital in Tunis, Tunisia, 1999-2005 [J].

Elhani, D. ;

Bakir, L. ;

Aouni, M. ;

Passet, V. ;

Arlet, G. ;

Brisse, S. ;

Weill, F. -X. .

CLINICAL MICROBIOLOGY AND INFECTION, 2010, 16 (02) :157-164

[8] eBURST: Inferring patterns of evolutionary descent among clusters of related bacterial genotypes from multilocus sequence typing data [J].

Feil, EJ ;

Li, BC ;

Aanensen, DM ;

Hanage, WP ;

Spratt, BG .

JOURNAL OF BACTERIOLOGY, 2004, 186 (05) :1518-1530

[9] Molecular epidemiology of the integron-located VEB-1 extended-spectrum β-lactamase in nosocomial enterobacterial isolates in Bangkok, Thailand [J].

Girlich, D ;

Poirel, L ;

Leelaporn, A ;

Karim, A ;

Tribuddharat, C ;

Fennewald, M ;

Nordmann, P .

JOURNAL OF CLINICAL MICROBIOLOGY, 2001, 39 (01) :175-182

[10] Investigation of extended-spectrum β-lactamases produced by clinical isolates of Klebsiella pneumoniae and Escherichia coli in Korea [J].

Jeong, SH ;

Bae, IK ;

Kwon, SB ;

Lee, JH ;

Jung, HI ;

Song, JS ;

Jeong, BC ;

Kim, SJ ;

Lee, SH .

LETTERS IN APPLIED MICROBIOLOGY, 2004, 39 (01) :41-47

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