Total synthesis of bastadins 2, 3, and 6

被引：29

作者：

Guo, ZW ^{[1
]}

Machiya, K ^{[1
]}

Salamonczyk, GM ^{[1
]}

Sih, CJ ^{[1
]}

机构：

[1] Univ Wisconsin, Sch Pharm, Madison, WI 53706 USA

来源：

JOURNAL OF ORGANIC CHEMISTRY | 1998年 / 63卷 / 13期

关键词：

D O I：

10.1021/jo9721204

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A chemoenzymatic strategy has been developed for the synthesis of bastadins 2, 3, and 6. The requisite dimeric dityrosine and isodityrosine building blocks were successfully prepared by oxidative C-C and C-O phenolic coupling of mono- and dihalogenated derivatives of tyrosine and tyramine using horseradish and soybean peroxidases. By carefully controlling the experimental parameters, the requisite synthons may now be prepared in synthetically useful yields without the exhaustive protection and deprotection of the sensitive functional groups.

引用

页码：4269 / 4276

页数：8

共 23 条

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