Conserved Fungal LysM Effector Ecp6 Prevents Chitin-Triggered Immunity in Plants

被引：545

作者：

de Jonge, Ronnie ^{[1
]}

van Esse, H. Peter ^{[1
]}

Kombrink, Anja ^{[1
]}

Shinya, Tomonori ^{[3
]}

Desaki, Yoshitake ^{[3
]}

Bours, Ralph ^{[4
]}

van der Krol, Sander ^{[4
]}

Shibuya, Naoto ^{[3
]}

Joosten, Matthieu H. A. J. ^{[1
]}

Thomma, Bart P. H. J. ^{[1
,2
]}

机构：

[1] Wageningen Univ, Phytopathol Lab, NL-6708 PB Wageningen, Netherlands

[2] Ctr Biosyst Genom, NL-6700 AB Wageningen, Netherlands

[3] Meiji Univ, Fac Agr, Dept Life Sci, Kanagawa 2148571, Japan

[4] Wageningen Univ, Lab Plant Physiol, NL-6708 PB Wageningen, Netherlands

来源：

SCIENCE | 2010年 / 329卷 / 5994期

关键词：

RECEPTOR-LIKE KINASE; CLADOSPORIUM-FULVUM; VIRULENCE FACTOR; BINDING; DEFENSE; TOMATO; CELLS; AVR4; RECOGNITION; ARABIDOPSIS;

D O I：

10.1126/science.1190859

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Multicellular organisms activate immunity upon recognition of pathogen-associated molecular patterns (PAMPs). Chitin is the major component of fungal cell walls, and chitin oligosaccharides act as PAMPs in plant and mammalian cells. Microbial pathogens deliver effector proteins to suppress PAMP-triggered host immunity and to establish infection. Here, we show that the LysM domain-containing effector protein Ecp6 of the fungal plant pathogen Cladosporium fulvum mediates virulence through perturbation of chitin-triggered host immunity. During infection, Ecp6 sequesters chitin oligosaccharides that are released from the cell walls of invading hyphae to prevent elicitation of host immunity. This may represent a common strategy of host immune suppression by fungal pathogens, because LysM effectors are widely conserved in the fungal kingdom.

引用

页码：953 / 955

页数：3

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