Antioxidants in health and disease

被引：1263

作者：

Young, IS

Woodside, JV

机构：

[1] Royal Grp Hosp, Inst Clin Sci, Dept Clin Biochem, Belfast BT12 6BJ, Antrim, North Ireland

[2] UCL Royal Free & UCL Med Sch, Dept Surg, London W1P 7LD, England

来源：

JOURNAL OF CLINICAL PATHOLOGY | 2001年 / 54卷 / 03期

关键词：

free radicals; antioxidants; oxidative stress; coronary heart disease; atherosclerosis;

D O I：

10.1136/jcp.54.3.176

中图分类号：

R36 [病理学];

学科分类号：

100104 [病理学与病理生理学];

摘要：

Free radical production occurs continuously in all cells as part of normal cellular function. However, excess free radical production originating from endogenous or exogenous sources might play a role in many diseases. Antioxidants prevent free radical induced tissue damage by preventing the formation of radicals, scavenging them, or by promoting their decomposition. This article reviews the basic chemistry of free radical formation in the body, the consequences of free radical induced tissue damage, and the function of antioxidant defence systems, with particular reference to the development of atherosclerosis.

引用

页码：176 / 186

页数：11

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