Direct synthesis of an oligonucleotide-poly(phenylene ethynylene) conjugate with a precise one-to-one molecular ratio

被引：93

作者：

Yang, CYJ ^{[1
]}

Pinto, M ^{[1
]}

Schanze, K ^{[1
]}

Tan, WH ^{[1
]}

机构：

[1] Univ Florida, Dept Chem, Ctr Res Bio Nano Interface, Gainesville, FL 32611 USA

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2005年 / 44卷 / 17期

关键词：

biosensors; conjugated polymers; fluorescent probes; molecular beacons; oligonucleotides;

D O I：

10.1002/anie.200462431

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

(Figure Presented) Polymer probes light up: Amplifying fluorescent polymers conjugated with biomolecules have excellent light-harvesting and superquenching properties (see scheme). A novel synthetic method is reported for the highly efficient, simple, fast, and readily controllable conjugation of a water-soluble poly(phenylene ethynylene) with an oligonucleotide. © 2005 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

页码：2572 / 2576

页数：5

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