Live attenuated mutants of Mycobacterium tuberculosis as candidate vaccines against tuberculosis

被引：53

作者：

Sambandamurthy, VK ^{[1
]}

Jacobs, WR ^{[1
]}

机构：

[1] Yeshiva Univ Albert Einstein Coll Med, Howard Hughes Med Inst, Dept Microbiol & Immunol, Bronx, NY 10461 USA

来源：

MICROBES AND INFECTION | 2005年 / 7卷 / 5-6期

关键词：

attenuated; double deletion pantothenate; tuberculosis; vaccine;

D O I：

10.1016/j.micinf.2005.04.001

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The recent advances in genetic tools to manipulate Mycobacterium tuberculosis have led to the construction of defined mutants and to the study of their role in the virulence and pathogenesis of tuberculosis. The safety and vaccine potential of a few of these M. tuberculosis mutants as candidate vaccines against tuberculosis are discussed. (c) 2005 Elsevier SAS. All rights reserved.

引用

页码：955 / 961

页数：7

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