Direct Transcriptional Targets of Sex Steroid Hormones in Bone

被引:78
作者
Krum, Susan A. [1 ]
机构
[1] Univ Calif Los Angeles, David Geffen Sch Med, Dept Orthopaed Surg, UCLA Orthopaed Hosp, Los Angeles, CA 90095 USA
关键词
ESTROGEN; ANDROGEN; BONE; TRANSCRIPTION; STEROID HORMONES; ESTROGEN-RECEPTOR-ALPHA; OSTEOBLAST-LIKE CELLS; GROWTH-FACTOR-BETA; FACTOR-KAPPA-B; GENE-EXPRESSION; ANDROGEN RECEPTOR; OSTEOPROTEGERIN PRODUCTION; AROMATASE DEFICIENCY; ENHANCER ELEMENTS; FEMALE MICE;
D O I
10.1002/jcb.22970
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
070307 [化学生物学]; 071010 [生物化学与分子生物学];
摘要
The sex steroid hormones, androgens and estrogens, via their respective nuclear receptors, regulate bone mineral density in humans and mice. Very little is known about the direct targets of the androgen and estrogen receptors in bone cells. First, models of hormone and receptor deficiency in mouse and human bone are discussed. This review then focuses on the direct targets of the receptors in osteoblasts and osteoclasts. A direct target of a NR is defined here as a gene that is regulated by NR binding to the DNA (either through DNA binding or association with a DNA binding protein) at an enhancer or promoter of that gene. The experimental evidence that illustrates androgen and estrogen gene regulation in osteoblasts and osteoclasts will be summarized and compared with the phenotype of the hormones in vivo. J. Cell. Biochem. 112: 401-408, 2011. (C) 2011 Wiley-Liss, Inc.
引用
收藏
页码:401 / 408
页数:8
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