Genome-wide association scan identifies a colorectal cancer susceptibility locus on chromosome 8q24

被引：577

作者：

Zanke, Brent W.

Greenwood, Celia M. T.

Rangrej, Jagadish

Kustra, Rafal

Tenesa, Albert

Farrington, Susan M.

Prendergast, James

Olschwang, Sylviane

Chiang, Theodore

Crowdy, Edgar

Ferretti, Vincent

Laflamme, Philippe

Sundararajan, Saravanan

Roumy, Stephanie

Olivier, Jean-Francois

Robidoux, Frederick

Sladek, Robert

Montpetit, Alexandre

Campbell, Peter

Bezieau, Stephane

O'Shea, Anne Marie

Zogopoulos, George

Cotterchio, Michelle

Newcomb, Polly

McLaughlin, John

Younghusband, Ban

Green, Roger

Green, Jane

Porteous, Mary E. M.

Campbell, Harry

Blanche, Helene

Sahbatou, Mourad

Tubacher, Emmanuel

Bonaiti-Pellie, Catherine

Buecher, Bruno

Riboli, Elio

Kury, Sebastien

Chanock, Stephen J.

Potter, John

Thomas, Gilles

Gallinger, Steven

Hudson, Thomas J.

Dunlop, Malcolm G.

机构：

[1] Ontario Inst Canc Res, Toronto, ON M5G 2L7, Canada

[2] Canc Care Ontario, Toronto, ON M5G 1L7, Canada

[3] Univ Ottawa, Fac Med, Div Hematol, Ottawa, ON K1H 8L6, Canada

[4] Hosp Sick Children, Toronto, ON M5G 1L7, Canada

[5] Univ Toronto, Dept Publ Hlth Sci, Toronto, ON M5T 3M7, Canada

[6] Univ Edinburgh, Canc Res Ctr, Colon Canc Genet Grp, Edinburgh EH4 2XU, Midlothian, Scotland

[7] Western Gen Hosp, Human Genet Unit, UK Med Res Council, Edinburgh EH4 2XU, Midlothian, Scotland

[8] Inst J Paoli I Calmettes, INSERM, U599, F-13009 Marseille, France

[9] McGill Univ, Montreal, PQ H3G 1A4, Canada

[10] Genome Quebec Innovat Ctr, Montreal, PQ H3G 1A4, Canada

[11] Mt Sinai Hosp, Samuel Lunenfeld Res Inst, Toronto, ON M5G 1X5, Canada

[12] Univ Toronto, Toronto, ON M5G 1X5, Canada

[13] Ctr Hosp Univ Hotel Dieu, IMAD, F-44093 Nantes 01, France

[14] Ctr Hosp Univ Hotel Dieu, EA3823, F-44093 Nantes 01, France

[15] Fred Hutchinson Canc Res Ctr, Seattle, WA 98109 USA

[16] Mem Univ Newfoundland, St John, NF A1C 5S7, Canada

[17] Univ Edinburgh, Dept Clin Genet, Edinburgh EH4 2XU, Midlothian, Scotland

[18] Univ Edinburgh, Edinburgh EH8 9AG, Midlothian, Scotland

[19] Ctr Etud Polymorphisme Humain, F-75010 Paris, France

[20] Hop Paul Brousse, INSERM, U535, F-94800 Villejuif, France

[21] Imperial Coll, Fac Med, London W2 1PG, England

[22] NCI, Canc Res Ctr, NIH, DHHS, Gaithersburg, MD 20877 USA

[23] NCI, Div Canc Genet & Epidemiol, NIH, DHHS, Gaithersburg, MD 20877 USA

[24] NCI, Div Canc Epidemiol & Genet, Bethesda, MD 20892 USA

来源：

NATURE GENETICS | 2007年 / 39卷 / 08期

基金：

英国医学研究理事会;

关键词：

PROSTATE-CANCER;

D O I：

10.1038/ng2089

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Using a multistage genetic association approach comprising 7,480 affected individuals and 7,779 controls, we identified markers in chromosomal region 8q24 associated with colorectal cancer. In stage 1, we genotyped 99,632 SNPs in 1,257 affected individuals and 1,336 controls from Ontario. In stages 2-4, we performed serial replication studies using 4,024 affected individuals and 4,042 controls from Seattle, Newfoundland and Scotland. We identified one locus on chromosome 8q24 and another on 9p24 having combined odds ratios (OR) for stages 1-4 of 1.18 (trend; P = 1.41 x 10(-8)) and 1.14 (trend; P = 1.32 x 10(-5)), respectively. Additional analyses in 2,199 affected individuals and 2,401 controls from France and Europe supported the association at the 8q24 locus (OR = 1.16, trend; 95% confidence interval (c.i.): 1.07-1.26; P = 5.05 = 10-4). A summary across all seven studies at the 8q24 locus was highly significant (OR = 1.17, c.i.: 1.12-1.23; P = 3.16 x 10(-11)). This locus has also been implicated in prostate cancer(1-3).

引用

页码：989 / 994

页数：6

共 13 条

[1] A common variant associated with prostate cancer in European and African populations [J].

Amundadottir, Laufey T. ;

Sulem, Patrick ;

Gudmundsson, Julius ;

Helgason, Agnar ;

Baker, Adam ;

Agnarsson, Bjarni A. ;

Sigurdsson, Asgeir ;

Benediktsdottir, Kristrun R. ;

Cazier, Jean-Baptiste ;

Sainz, Jesus ;

Jakobsdottir, Margret ;

Kostic, Jelena ;

Magnusdottir, Droplaug N. ;

Ghosh, Shyamali ;

Agnarsson, Kari ;

Birgisdottir, Birgitta ;

Le Roux, Louise ;

Olafsdottir, Adalheidur ;

Blondal, Thorarinn ;

Andresdottir, Margret ;

Gretarsdottir, Olafia Svandis ;

Bergthorsson, Jon T. ;

Gudbjartsson, Daniel ;

Gylfason, Arnaldur ;

Thorleifsson, Gudmar ;

Manolescu, Andrei ;

Kristjansson, Kristleifur ;

Geirsson, Gudmundur ;

Isaksson, Helgi ;

Douglas, Julie ;

Johansson, Jan-Erik ;

Balter, Katarina ;

Wiklund, Fredrik ;

Montie, James E. ;

Yu, Xiaoying ;

Suarez, Brian K. ;

Ober, Carole ;

Cooney, Kathleen A. ;

Gronberg, Henrik ;

Catalona, William J. ;

Einarsson, Gudmundur V. ;

Barkardottir, Rosa B. ;

Gulcher, Jeffrey R. ;

Kong, Augustine ;

Thorsteinsdottir, Unnur ;

Stefansson, Kari .

NATURE GENETICS, 2006, 38 (06) :652-658

[2] CONTROLLING THE FALSE DISCOVERY RATE - A PRACTICAL AND POWERFUL APPROACH TO MULTIPLE TESTING [J].

BENJAMINI, Y ;

HOCHBERG, Y .

JOURNAL OF THE ROYAL STATISTICAL SOCIETY SERIES B-STATISTICAL METHODOLOGY, 1995, 57 (01) :289-300

[3]

Cotterchio M, 2000, Chronic Dis Can, V21, P81

[4] METAANALYSIS IN CLINICAL-TRIALS [J].

DERSIMONIAN, R ;

LAIRD, N .

CONTROLLED CLINICAL TRIALS, 1986, 7 (03) :177-188

[5] Illumina universal bead arrays [J].

Fan, Jian-Bing ;

Gunderson, Kevin L. ;

Bibikova, Marina ;

Yeakley, Joanne M. ;

Chen, Jing ;

Wickham Garcia, Eliza ;

Lebruska, Lori L. ;

Laurent, Marc ;

Shen, Richard ;

Barker, David .

DNA MICROARRAYS PART A: ARRAY PLATFORMS AND WET-BENCH PROTOCOLS, 2006, 410 :57-+

[6] Optimal selection of markers for validation or replication from genome-wide association studies [J].

Greenwood, Celia M. T. ;

Rangrej, Jagadish ;

Sun, Lei .

GENETIC EPIDEMIOLOGY, 2007, 31 (05) :396-407

[7] Genome-wide association study identifies a second prostate cancer susceptibility variant at 8q24 [J].

Gudmundsson, Julius ;

Sulem, Patrick ;

Manolescu, Andrei ;

Amundadottir, Laufey T. ;

Gudbjartsson, Daniel ;

Helgason, Agnar ;

Rafnar, Thorunn ;

Bergthorsson, Jon T. ;

Agnarsson, Bjarni A. ;

Baker, Adam ;

Sigurdsson, Asgeir ;

Benediktsdottir, Kristrun R. ;

Jakobsdottir, Margret ;

Xu, Jianfeng ;

Blondal, Thorarinn ;

Kostic, Jelena ;

Sun, Jielin ;

Ghosh, Shyamali ;

Stacey, Simon N. ;

Mouy, Magali ;

Saemundsdottir, Jona ;

Backman, Valgerdur M. ;

Kristjansson, Kristleifur ;

Tres, Alejandro ;

Partin, Alan W. ;

Albers-Akkers, Marjo T. ;

Marcos, Javier Godino-Ivan ;

Walsh, Patrick C. ;

Swinkels, Dorine W. ;

Navarrete, Sebastian ;

Isaacs, Sarah D. ;

Aben, Katja K. ;

Graif, Theresa ;

Cashy, John ;

Ruiz-Echarri, Manuel ;

Wiley, Kathleen E. ;

Suarez, Brian K. ;

Witjes, J. Alfred ;

Frigge, Mike ;

Ober, Carole ;

Jonsson, Eirikur ;

Einarsson, Gudmundur V. ;

Mayordomo, Jose I. ;

Kiemeney, Lambertus A. ;

Isaacs, William B. ;

Catalona, William J. ;

Barkardottir, Rosa B. ;

Gulcher, Jeffrey R. ;

Thorsteinsdottir, Unnur ;

Kong, Augustine .

NATURE GENETICS, 2007, 39 (05) :631-637

[8] Multiple regions within 8q24 independently affect risk for prostate cancer [J].

Haiman, Christopher A. ;

Patterson, Nick ;

Freedman, Matthew L. ;

Myers, Simon R. ;

Pike, Malcolm C. ;

Waliszewska, Alicja ;

Neubauer, Julie ;

Tandon, Arti ;

Schirmer, Christine ;

McDonald, Gavin J. ;

Greenway, Steven C. ;

Stram, Daniel O. ;

Le Marchand, Loic ;

Kolonel, Laurence N. ;

Frasco, Melissa ;

Wong, David ;

Pooler, Loreall C. ;

Ardlie, Kristin ;

Oakley-Girvan, Ingrid ;

Whittemore, Alice S. ;

Cooney, Kathleen A. ;

John, Esther M. ;

Ingles, Sue A. ;

Altshuler, David ;

Henderson, Brian E. ;

Reich, David .

NATURE GENETICS, 2007, 39 (05) :638-644

[9] Environmental and heritable factors in the causation of cancer - Analyses of cohorts of twins from Sweden, Denmark, and Finland. [J].

Lichtenstein, P ;

Holm, NV ;

Verkasalo, PK ;

Iliadou, A ;

Kaprio, J ;

Koskenvuo, M ;

Pukkala, E ;

Skytthe, A ;

Hemminki, K .

NEW ENGLAND JOURNAL OF MEDICINE, 2000, 343 (02) :78-85

[10] Coverage and characteristics of the affymetrix GeneChip human mapping 100K SNP set [J].

Nicolae, Dan L. ;

Wen, Xiaoquan ;

Voight, Benjamin F. ;

Cox, Nancy J. .

PLOS GENETICS, 2006, 2 (05) :665-671

← 1 2 →