Fabrication of thermosensitive, star-shaped poly(L-lactide)-block-poly(N-isopropylacrylamide) copolymers with porphyrin core for photodynamic therapy

被引：32

作者：

Dai, Xiao-Hui ^{[1
,3
]}

Jin, Hua ^{[1
]}

Cai, Mei-Hong ^{[2
]}

Wang, Hao ^{[4
]}

Zhou, Zhi-Ping ^{[4
]}

Pan, Jian-Ming ^{[1
]}

Wang, Xiao-Hong ^{[1
]}

Yan, Yong-Sheng ^{[1
,3
]}

Liu, Dong-Ming ^{[4
]}

Sun, Lin ^{[5
]}

机构：

[1] Jiangsu Univ, Sch Chem & Chem Engn, Dept Chem Engn, Zhenjiang 212013, Peoples R China

[2] Jiangsu Univ, Sch Chem & Chem Engn, Sch Food & Biol Engn, Zhenjiang 212013, Peoples R China

[3] Peking Univ, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China

[4] Jiangsu Univ, Hosp Affiliated, Zhenjiang 212013, Peoples R China

[5] CSR Qingdao Sifang Co Ltd, Qingdao 266111, Shandong, Peoples R China

来源：

REACTIVE & FUNCTIONAL POLYMERS | 2015年 / 89卷

基金：

中国国家自然科学基金;

关键词：

Thermosensitive; RAFT; Porphyrin; Star-shaped; PDT; DRUG-DELIVERY; N-ISOPROPYLACRYLAMIDE; BLOCK-COPOLYMERS; MICELLES; AGGREGATION; CANCER; POLY(N-ISOPROPYLACRYLAMIDE); PHOTOSENSITIZER; POLYMERIZATION; MICELLIZATION;

D O I：

10.1016/j.reactfunctpolym.2015.02.002

中图分类号：

O69 [应用化学];

学科分类号：

070301 [无机化学];

摘要：

Thermosensitive, star-shaped porphyrin-cored poly(L-lactide)-block-poly(N-isopropylacrylamide) (SPPLA-PNIPAM) was synthesized via ring-opening polymerization (ROP) and reversible addition-fragmentation chain transfer polymerization (RAFT). The composition and properties of copolymer were discussed based on the results of NMR, IR and GPC. With PNIPAM block length decreasing, the morphology of SPPLA-PNIPAM copolymer in aqueous solution transformed hierarchically from spherical micelles through wormlike micelles to vesicles, and the lower critical solution temperatures (LCST) of the copolymer solutions were determined to be 37.9 degrees, 37.2 degrees, 35.9 degrees, respectively. The in vitro study indicated that SPPLA-PNIPAM showed no significant dark cytotoxicity at concentrations up to 128 mu g/mL, while showed apparent phototoxicity toward BEL-7402 cancer cells. Considering a high singlet oxygen quantum yield and suitable nominal physiologic LCST, it is expected that the SPPLA-PNIPAM copolymer is a promising stimulus-responsive candidate which has a potential application in photodynamic therapy (PDT). (C) 2015 Elsevier B.V. All rights reserved.

引用

页码：9 / 17

页数：9

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