Role of autologous stem-cell transplantation in multiple myeloma

被引：19

作者：

Attal, Michel ^{[2
]}

Harousseau, Jean-Luc ^{[1
]}

机构：

[1] Hop Hotel Dieu, Ctr Hosp Univ, F-44093 Nantes 01, France

[2] CHU Purpan, Dept Hematol, F-31059 Toulouse, France

来源：

BEST PRACTICE & RESEARCH CLINICAL HAEMATOLOGY | 2007年 / 20卷 / 04期

关键词：

multiple myeloma; high-dose therapy; autologous stem-cell transplantation; double transplantation; novel agents; thalidomide; bortezomib; lenalidomide; induction; maintenance;

D O I：

10.1016/j.beha.2007.09.006

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Multiple myeloma (MM) is one of the diseases in which the impact of dose intensity has been demonstrated. Consequently, in 2005 MM was the first disease for which autologous stem-cell transplantation (ASCT) was indicated in Europe and the US. However, ASCT is not curative, and most patients relapse in a median of 3 years. The introduction of novel agents such as thalidomide, bortezomib (Velcade (R)) or lenalidomide (Revlimid (R)) was logical to try to improve the high-dose strategy, and promising results have been reported. This article will focus on the current results of ASCT and will discuss the main research area to try to improve this strategy.

引用

页码：747 / 759

页数：13

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