Caspase activation as an apoptotic evidence in the gerbil hippocampal CA1 pyramidal cells following transient forebrain ischemia

被引：51

作者：

Niwa, M

Hara, A

Iwai, T

Wang, S

Hotta, K

Mori, H

Uematsu, T

机构：

[1] Gifu Univ, Sch Med, Dept Pharmacol, Gifu 5008705, Japan

[2] Gifu Univ, Sch Med, Dept Pathol, Gifu 500, Japan

[3] Gifu Municipal Hosp, Div Neurosurg, Gifu, Japan

来源：

NEUROSCIENCE LETTERS | 2001年 / 300卷 / 02期

关键词：

delayed neuronal death; gerbil; forebrain ischemia; caspase; DNA fragmentation;

D O I：

10.1016/S0304-3940(01)01559-2

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

To determine whether apoptotic process is involved in the delayed neuronal death in hippocampal CA1 region following forebrain ischemia in gerbils, time dependent activation of caspase and DNA fragmentation were evaluated by immune-staining and terminal dUTP nick-end-labeling staining, respectively. After transient forebrain ischemia in gerbils, activation of apoptosis related caspase, including caspase-3, was apparent, and it preceded DNA fragmentation in CA1 region, These observations suggest that apoptotic process is involved in hippocampal delayed neuronal death. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：103 / 106

页数：4

共 21 条

[1] Continuing postischemic neuronal death in CA1 - Influence of ischemia duration and cytoprotective doses of NBQX and SNX-111 in rats [J].