Effect of carbohydrate ingestion on glucose kinetics during exercise in the heat

Six endurance-trained men (peak oxy gen uptake ((V) over dotO(2)) = 4.58 +/- 0.50 (SE) l/min] completed 60 min of exercise at a workload requiring 68 +/- 2% peak (V) over dotO(2) in an environmental chamber maintained at 35 degreesC (<50% relative humidity) on two occasions, separated by at least 1 wk. Subjects ingested either a 6% glucose solution containing 1 <mu>Ci [3-H-3]glucose/g glucose (CHO trial) or a sweet placebo (Con trial) during the trials. Rates of hepatic glucose production [HGP = glucose rate of appearance (R-a) in Con trial] and glucose disappearance (R-d), were measured using a primed, continuous infusion of [6,6-H-2]glucose, corrected for gut-derived glucose (gut R-a) in the CHO trial. No differences in heart rate, (V) over dotO(2), respiratory exchange ratio, or rectal temper ature were observed between trials. Plasma glucose concentrations were similar at rest but increased (P < 0.05) to a greater extent in the CHO trial compared with the Con trial. This was due to the absorption of ingested glucose in the CHO trial, because gut R-a after 30 and 50 min (16 +/- 5 <mu>mol.kg(-1).min(-1)) was higher (P < 0.05) compared with rest, whereas HGP during exercise was not different between trials. Glucose R-d was higher (P < 0.05) in the CHO trial after 30 and 50 min (48.0 +/- 6.3 vs 34.6 +/- 3.8 mu mol.kg(-1).min(-1), CHO vs. Con, respectively). These results indicate that ingestion of carbohydrate, at a rate of similar to1.0 g/min, increases glucose R-d but does not blunt the rise in HGP during exercise in the heat.