Macrocyclic and helical oligoamides as a new class of g-quadruplex ligands

被引：155

作者：

Shirude, Pravin S.

Gillies, Elizabeth R.

Ladame, Sylvain

Godde, Frederic

Shin-Ya, Kazuo

Huc, Ivan

Balasubramanian, Shankar

机构：

[1] Univ Bordeaux 1, Inst Europeen Chim & Biol, CNRS, UMR 5248, F-33607 Pessac, France

[2] Univ Cambridge, Univ Chem Lab, Cambridge CB2 1EW, England

[3] Natl Inst Adv Ind Sci & Technol, Chem Biol Team, BIRC, Tokyo 1008921, Japan

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2007年 / 129卷 / 39期

关键词：

D O I：

10.1021/ja073775h

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A planar trimeric macrocyclic oligoamide of 8-amino-2-quinoline carboxylic acid, bearing ammonium side chains, stabilizes the human telomeric G-quadruplex more strongly than the potent ligand telomestatin. Furthermore, a helical oligoamide tetramer also binds strongly to G-quadruplexes and is a new structural class of quadruplex ligand that appears to interact enantioselectively.

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页码：11890 / +

页数：3

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