Development and biological assessment of fully water-soluble helical aromatic amide foldamers

被引：93

作者：

Gillies, Elizabeth R.

Deiss, Frederique

Staedel, Cathy

Schmitter, Jean-Marie

Huc, Ivan

机构：

[1] Univ Bordeaux 1, CNRS, UMR5248, Inst European Chim & Biol, F-33607 Pessac, France

[2] Univ Bordeaux 2, INSERM, U869, F-33076 Bordeaux, France

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2007年 / 46卷 / 22期

关键词：

drug delivery; helical structures; medicinal chemistry; peptidomimetics;

D O I：

10.1002/anie.200700301

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Abiotic but bioactive: Folding aromatic amide oligomers possessing helical structures very different from those of α-peptides, β-peptides, or peptoids nevertheless show comparable abilities to penetrate into cells, as well as low toxicity and complete resistance to protease degradation. TFA - = trifluoroacetate. (Chemical Equation Presented) © 2007 Wiley-VCH Verlag GmbH & Co. KGaA.

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页码：4081 / 4084

页数：4

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