Epigenomics reveals a functional genome anatomy and a new approach to common disease

被引：86

作者：

Feinberg, Andrew P. ^{[1
,2
]}

机构：

[1] Johns Hopkins Univ, Sch Med, Ctr Epigenet, Baltimore, MD 21218 USA

[2] Johns Hopkins Univ, Sch Med, Dept Med, Baltimore, MD 21205 USA

来源：

NATURE BIOTECHNOLOGY | 2010年 / 28卷 / 10期

关键词：

EMBRYONIC STEM-CELLS; CPG ISLAND SHORES; DNA METHYLATION; ANTISENSE RNA; CANCER; CHROMATIN; GENES; TRANSCRIPTION; ORGANIZATION; PLURIPOTENT;

D O I：

10.1038/nbt1010-1049

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Epigenomics provides the context for understanding the function of genome sequence, analogous to the functional anatomy of the human body provided by Vesalius a half-millennium ago. Much of the seemingly inconclusive genetic data related to common diseases could therefore become meaningful in an epigenomic context.

引用

页码：1049 / 1052

页数：4

共 42 条

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